Histona deacetilasa 1

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Histona deacetilasa 1
Estructuras disponibles
PDB Búsqueda en Ortholog: PDBeRCSB
Identificadores
Símbolos HDAC1 (HUGO: 4852); DKFZp686H12203; GON-10; HD1; RPD3; RPD3L1
Identificadores externos OMIM601241 MGI108086 HomoloGene68426 ChEMBL325 GeneCardsGen HDAC1
Número EC 3.5.1.98
Locus Cr. 1 p35.1
Patrones de expresión RNA
PBB GE HDAC1 201209 at tn.png
Mayor información
Ortología
Especies Humano Ratón
Entrez 3065 433759
Ensembl Véase HS Véase MM
UniProt Q13547 O09106
RefSeq (mRNA) NM_004964 NM_008228
RefSeq (proteína) NCBI NP_004955 NP_032254
Ubicación (UCSC) Chr 1:
32.76 – 32.8 Mb
Chr 4:
129.52 – 129.54 Mb
PubMed (búsqueda) [1] [2]

La histona deacetilasa 1 (HDAC1) es una enzima codificada en humanos por el gen hdac1.[1]

Función[editar]

Las histonas juegan un papel crucial en la regulación de la transcripción, en la progresión del ciclo celular y en procesos de desarrollo. La acetilación/desacetilación de histonas altera la estructura del cromosoma, variando así la accesibilidad de los factores de transcripción al ADN. La HDAC1 pertenece a la familia de histona deacetilasas acuc/alfa y es uno de los componentes del complejo histona deacetilasa. Esta proteína interacciona con la proteína del retinoblastoma formando un complejo que es un elemento clave en el control de la proliferación celular y la diferenciación celular. Junto con la proteína 2 asociada a metástasis, deacetila a p53 y modula su acción sobre la proliferación celular y la apoptosis.[2]

Interacciones[editar]

La histona deacetilasa 1 ha demostrado ser capaz de interaccionar con:

Véase también[editar]

Referencias[editar]

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