RELA

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Factor de transcripción p65

Estructura tridimensional de la proteína RELA.
Estructuras disponibles
PDB Búsqueda en Human Uniprot: PDBeRCSB
Identificadores
Símbolos RELA (HUGO: 9955); MGC131774; NFKB3
Identificadores externos OMIM164014 GeneCardsGen RELA
Locus Cr. 11 q13.1
Ortología
Especies Humano Ratón
Entrez 5970 n/a
UniProt Q04206 n/a
RefSeq (mRNA) NP_068810 n/a

El factor de transcripción p65 (RELA) es una proteína codificada en humanos por el gen RELA.[1]

NFKB1 o NFKB2 se unen a REL, RELA o RELB para formar el complejo NFKB. El heterodímero p50/p65 (NFKB1/RELA) es la forma más abundante de complejo NFKB. Este complejo es inhibido por proteínas IκB (NFKBIA o NFKBIB), que inactivan a NFKB secuestrándolo y reteniéndolo en el citoplasma. La fosforilación de los residuos de serina de las proteínas IκB mediante la acción de quinasas como IKBKA o IKBKB, las marca para ser degradadas por una ruta de ubiquitinación, permitiendo la activación del complejo NFKB. El complejo NFKB activado se trasloca al núcleo celular y se une al ADN en motivos de unión kappa-B, tales como las secuencias de nucleótidos 5'-GGGRNNYYCC-3' ó 5'-HGGARNYYCC-3' (donde H es A, C o T; R es una purina, A o G; Y es una pirimidina, C o T).[2]

Interacciones[editar]

La proteína RELA ha demostrado ser capaz de interaccionar con:

Referencias[editar]

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  42. Jung, Dong-Ju; Sung Hee-Sook, Goo Young-Wha, Lee Hyun Mi, Park Ok Ku, Jung Sung-Yun, Lim Janghoo, Kim Han-Jong, Lee Soo-Kyung, Kim Tae Sung, Lee Jae Woon, Lee Young Chul (Jul. 2002). «Novel transcription coactivator complex containing activating signal cointegrator 1». Mol. Cell. Biol. (United States) 22 (14):  pp. 5203–11. ISSN 0270-7306. PMID 12077347. 
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Enlaces externos[editar]