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Proteína de unión a ADN Ikaros
Símbolos IKZF1 (HUGO: 13176); IK1; Hs.54452; IKAROS; LYF1; PRO0758; ZNFN1A1; hIk-1
Identificadores externos OMIM603023 GeneCardsGen IKZF1
Locus Cr. 7 p12.2
Especies Humano Ratón
Entrez 10320 n/a
UniProt Q13422 n/a
RefSeq (mRNA) NP_006051 n/a

La proteína de unión a ADN Ikaros (IKZF1) es una proteína codificada en humanos por el gen IKZF1.[1] [2] [3]

La proteína IKZF1 pertenece a la familia de proteínas con dedos de zinc.


La proteína IKZF1 ha demostrado ser capaz de interaccionar con:


  1. Georgopoulos K, Moore DD, Derfler B (Dec 1992). «Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment». Science 258 (5083):  pp. 808–12. PMID 1439790. 
  2. Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST (Nov 1994). «The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene». Mol Cell Biol 14 (11):  pp. 7111–23. PMID 7935426. 
  3. «Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros)».
  4. a b c d e Koipally, Joseph; Georgopoulos Katia (Aug. 2002). «A molecular dissection of the repression circuitry of Ikaros». J. Biol. Chem. (United States) 277 (31):  pp. 27697–705. doi:10.1074/jbc.M201694200. ISSN 0021-9258. PMID 12015313. 
  5. a b c Koipally, J; Renold A, Kim J, Georgopoulos K (Jun. 1999). «Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes». EMBO J. (ENGLAND) 18 (11):  pp. 3090–100. doi:10.1093/emboj/18.11.3090. ISSN 0261-4189. PMID 10357820. 
  6. Koipally, Joseph; Georgopoulos Katia (Jun. 2002). «Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression». J. Biol. Chem. (United States) 277 (26):  pp. 23143–9. doi:10.1074/jbc.M202079200. ISSN 0021-9258. PMID 11959865. 
  7. Honma, Y; Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, Tojo M, Takeda J, Tanno Y, Yokoya S, Kawabata I, Ikeda H, Wanaka A (Mar. 1999). «Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system». FEBS Lett. (NETHERLANDS) 447 (1):  pp. 76–80. ISSN 0014-5793. PMID 10218586. 
  8. Perdomo, J; Holmes M, Chong B, Crossley M (Dec. 2000). «Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities». J. Biol. Chem. (UNITED STATES) 275 (49):  pp. 38347–54. doi:10.1074/jbc.M005457200. ISSN 0021-9258. PMID 10978333. 
  9. Koipally, J; Georgopoulos K (Jun. 2000). «Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity». J. Biol. Chem. (UNITED STATES) 275 (26):  pp. 19594–602. doi:10.1074/jbc.M000254200. ISSN 0021-9258. PMID 10766745. 

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