RFC1

Subunidad 1 del factor C de replicación
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	RFC1 (HGNC: 9969) A1; MGC51786; MHCBFB; PO-GA; RECC1; RFC; RFC140
Identificadores; externos	OMIM: 102579 ; EBI: RFC1; GeneCards: Gen RFC1; UniProt: RFC1;
Locus	Cr. 4 p14
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
5981
P35251	n/a
NP_002904	n/a
	v; t; e;
	[editar datos en Wikidata]

La subunidad 1 del factor C de replicación (RFC1) es una proteína codificada en humanos por el gen RFC1.^[1]^[2]

La proteína RFC1 es la subunidad grande del factor C de replicación, que es una proteína accesoria de la ADN polimerasa, compuesta por cinco subunidades. El factor C de repliación es una ATPasa dependiente de ADN necesaria en los procesos de replicación y reparación del ADN. Esta proteína actúa como un activador de la ADN polimerasa, uniéndose al extremo 3' de los oligonucleótidos, y promoviendo una síntesis coordinada de las dos hebras de ADN. También podría desempeñar un papel en la estabilidad de los telómeros.^[2]

Interacciones[editar]

La proteína RFC1 ha demostrado ser capaz de interaccionar con:

BRD4^[3]
HDAC1^[4]
RFC3^[5]^[6]^[7]
RELA^[8]
PCNA^[3]^[9]^[10]^[11]^[12]

Referencias[editar]

↑ Luckow B, Bunz F, Stillman B, Lichter P, Schutz G (Mar de 1994). «Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans». Mol Cell Biol 14 (3): 1626-34. PMC 358521. PMID 8114700.
↑ ^a ^b «Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa».
↑ ^a ^b Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep. de 2002). «A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase». Mol. Cell. Biol. (United States) 22 (18): 6509-20. ISSN 0270-7306. PMID 12192049.
↑ Anderson, Lisa A; Perkins Neil D (Aug. de 2002). «The large subunit of replication factor C interacts with the histone deacetylase, HDAC1». J. Biol. Chem. (United States) 277 (33): 29550-4. ISSN 0021-9258. PMID 12045192. doi:10.1074/jbc.M200513200.
↑ Ellison, V; Stillman B (Mar. de 1998). «Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity». J. Biol. Chem. (UNITED STATES) 273 (10): 5979-87. ISSN 0021-9258. PMID 9488738.
↑ Uhlmann, F; Cai J, Flores-Rozas H, Dean F B, Finkelstein J, O'Donnell M, Hurwitz J (Jun. de 1996). «In vitro reconstitution of human replication factor C from its five subunits». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6521-6. ISSN 0027-8424. PMID 8692848.
↑ Tomida, Junya; Masuda Yuji, Hiroaki Hidekazu, Ishikawa Tomoko, Song Ihnyoung, Tsurimoto Toshiki, Tateishi Satoshi, Shiomi Tadahiro, Kamei Yasuhiro, Kim Jinhyeong, Kamiya Kenji, Vaziri Cyrus, Ohmori Haruo, Todo Takeshi (Apr. de 2008). «DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex». J. Biol. Chem. (United States) 283 (14): 9071-9. ISSN 0021-9258. PMID 18245774. doi:10.1074/jbc.M709835200.
↑ Anderson, Lisa A; Perkins Neil D (Jan. de 2003). «Regulation of RelA (p65) function by the large subunit of replication factor C». Mol. Cell. Biol. (United States) 23 (2): 721-32. ISSN 0270-7306. PMID 12509469.
↑ Fotedar, R; Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (Aug. de 1996). «A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells». EMBO J. (ENGLAND) 15 (16): 4423-33. ISSN 0261-4189. PMID 8861969.
↑ Mossi, R; Jónsson Z O, Allen B L, Hardin S H, Hübscher U (Jan. de 1997). «Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen». J. Biol. Chem. (UNITED STATES) 272 (3): 1769-76. ISSN 0021-9258. PMID 8999859.
↑ van der Kuip, H; Carius B, Haque S J, Williams B R, Huber C, Fischer T (Apr. de 1999). «The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins». J. Mol. Med. (GERMANY) 77 (4): 386-92. ISSN 0946-2716. PMID 10353443.
↑ Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct. de 2002). «A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein». J. Biol. Chem. (United States) 277 (43): 40362-7. ISSN 0021-9258. PMID 12171929. doi:10.1074/jbc.M206194200.

Datos: Q18031096

[pmid8114700-1] Luckow B, Bunz F, Stillman B, Lichter P, Schutz G (Mar de 1994). «Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans». Mol Cell Biol 14 (3): 1626-34. PMC 358521. PMID 8114700.

[entrez-2] «Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa».

[pmid12192049-3] Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep. de 2002). «A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase». Mol. Cell. Biol. (United States) 22 (18): 6509-20. ISSN 0270-7306. PMID 12192049.

[pmid12045192-4] Anderson, Lisa A; Perkins Neil D (Aug. de 2002). «The large subunit of replication factor C interacts with the histone deacetylase, HDAC1». J. Biol. Chem. (United States) 277 (33): 29550-4. ISSN 0021-9258. PMID 12045192. doi:10.1074/jbc.M200513200.

[pmid9488738-5] Ellison, V; Stillman B (Mar. de 1998). «Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity». J. Biol. Chem. (UNITED STATES) 273 (10): 5979-87. ISSN 0021-9258. PMID 9488738.

[pmid8692848-6] Uhlmann, F; Cai J, Flores-Rozas H, Dean F B, Finkelstein J, O'Donnell M, Hurwitz J (Jun. de 1996). «In vitro reconstitution of human replication factor C from its five subunits». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6521-6. ISSN 0027-8424. PMID 8692848.

[pmid18245774-7] Tomida, Junya; Masuda Yuji, Hiroaki Hidekazu, Ishikawa Tomoko, Song Ihnyoung, Tsurimoto Toshiki, Tateishi Satoshi, Shiomi Tadahiro, Kamei Yasuhiro, Kim Jinhyeong, Kamiya Kenji, Vaziri Cyrus, Ohmori Haruo, Todo Takeshi (Apr. de 2008). «DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex». J. Biol. Chem. (United States) 283 (14): 9071-9. ISSN 0021-9258. PMID 18245774. doi:10.1074/jbc.M709835200.

[pmid12509469-8] Anderson, Lisa A; Perkins Neil D (Jan. de 2003). «Regulation of RelA (p65) function by the large subunit of replication factor C». Mol. Cell. Biol. (United States) 23 (2): 721-32. ISSN 0270-7306. PMID 12509469.

[pmid8861969-9] Fotedar, R; Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (Aug. de 1996). «A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells». EMBO J. (ENGLAND) 15 (16): 4423-33. ISSN 0261-4189. PMID 8861969.

[pmid8999859-10] Mossi, R; Jónsson Z O, Allen B L, Hardin S H, Hübscher U (Jan. de 1997). «Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen». J. Biol. Chem. (UNITED STATES) 272 (3): 1769-76. ISSN 0021-9258. PMID 8999859.

[pmid10353443-11] van der Kuip, H; Carius B, Haque S J, Williams B R, Huber C, Fischer T (Apr. de 1999). «The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins». J. Mol. Med. (GERMANY) 77 (4): 386-92. ISSN 0946-2716. PMID 10353443.

[pmid12171929-12] Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct. de 2002). «A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein». J. Biol. Chem. (United States) 277 (43): 40362-7. ISSN 0021-9258. PMID 12171929. doi:10.1074/jbc.M206194200.

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