C-jun

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Oncogén JUN

Estructura tridimensional de la proteína c-Jun.
Estructuras disponibles
PDB Búsqueda en Ortholog: PDBeRCSB
Identificadores
Símbolos JUN (HUGO: 6204); AP1, c-Jun
Identificadores externos OMIM: 165160 HomoloGene: 1679 ChEMBL4977 GeneCardsGen JUN
Locus Cr. 1 p32.1
Patrones de expresión RNA
PBB GE JUN 201464 x at tn.png
PBB GE JUN 201465 s at tn.png
PBB GE JUN 201466 s at tn.png
Mayor información
Ortología
Especies Humano Ratón
Entrez 3725 16476
Ensembl Véase HS Véase MM
UniProt P05412 P05627
RefSeq (mRNA) NM_002228 NM_010591
RefSeq (proteína) NCBI NP_002219 NP_034721
Ubicación (UCSC) Chr 1:
59.25 – 59.25 Mb
Chr 4:
95.05 – 95.05 Mb
PubMed (búsqueda) [1] [2]

c-jun es el nombre de un gen que codifica la proteína c-Jun, la cual, tras combinarse con la proteína c-Fos, conforma el factor de transcripción AP-1. Inicialmente fue identificado como proteína p39 de unión a Fos y posteriormente fue redescubierta como el producto del gen c-jun. Su activación se produce por una doble fosforilación a través de la ruta JNK, pero también se ha descrito una función alternativa independiente de fosforilación. Se ha podido comprobar que el knockout de c-jun es letal. Sin embargo, animales transgénicos cuyo gen c-jun había sido mutado de modo que la proteína c-Jun no podía ser fosforilada (denominados c-JunAA), sí podían sobrevivir. La proteína c-Jun ha demostrado ser muy similar a una proteína del virus 17 de sarcoma aviar, la cual reconoce de un modo directo secuencias específicas del ADN para regular su expresión. El gen c-jun no posee intrones y se encuentra en una región cromosómica implicada en procesos de traslocaciones y deleciones en diversas patologías humanas.[1]

Interacciones[editar]

La proteína c-Jun ha demostrado ser capaz de interaccionar con:

Referencias[editar]

  1. «Entrez Gene: JUN jun oncogene». 
  2. Pessah, M; Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier J M, Atfi A (May. de 2001). «c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (11): 6198–203. doi:10.1073/pnas.101579798. ISSN 0027-8424. PMID 11371641. 
  3. Verger, A; Buisine E, Carrère S, Wintjens R, Flourens A, Coll J, Stéhelin D, Duterque-Coquillaud M (May. de 2001). «Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation». J. Biol. Chem. (United States) 276 (20): 17181–9. doi:10.1074/jbc.M010208200. ISSN 0021-9258. PMID 11278640. 
  4. Nishitani, J; Nishinaka T, Cheng C H, Rong W, Yokoyama K K, Chiu R (Feb. de 1999). «Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site». J. Biol. Chem. (UNITED STATES) 274 (9): 5454–61. ISSN 0021-9258. PMID 10026157. 
  5. Sano, Y; Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S (Oct. de 1998). «CBP alleviates the intramolecular inhibition of ATF-2 function». J. Biol. Chem. (UNITED STATES) 273 (44): 29098–105. ISSN 0021-9258. PMID 9786917. 
  6. Newell, C L; Deisseroth A B, Lopez-Berestein G (Jul. de 1994). «Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene». J. Leukoc. Biol. (UNITED STATES) 56 (1): 27–35. ISSN 0741-5400. PMID 8027667. 
  7. Kara, C J; Liou H C, Ivashkiv L B, Glimcher L H (Apr. de 1990). «A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain». Mol. Cell. Biol. (UNITED STATES) 10 (4): 1347–57. ISSN 0270-7306. PMID 2320002. 
  8. a b Hai, T; Curran T (May. de 1991). «Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 88 (9): 3720–4. ISSN 0027-8424. PMID 1827203. 
  9. Zhong, Hongjun; Zhu Jianhua, Zhang Hao, Ding Lihua, Sun Yan, Huang Cuifen, Ye Qinong (Dec. de 2004). «COBRA1 inhibits AP-1 transcriptional activity in transfected cells». Biochem. Biophys. Res. Commun. (United States) 325 (2): 568–73. doi:10.1016/j.bbrc.2004.10.079. ISSN 0006-291X. PMID 15530430. 
  10. Hu, Yan-Fen; Li Rong (Jun. de 2002). «JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction». Genes Dev. (United States) 16 (12): 1509–17. doi:10.1101/gad.995502. ISSN 0890-9369. PMID 12080089. 
  11. Ito, T; Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H (Jan. de 2001). «Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers». J. Biol. Chem. (United States) 276 (4): 2852–7. doi:10.1074/jbc.M009633200. ISSN 0021-9258. PMID 11053448. 
  12. a b Pognonec, P; Boulukos K E, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May. de 1997). «Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity». Oncogene (ENGLAND) 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. ISSN 0950-9232. PMID 9160889. 
  13. Glover, J N; Harrison S C (Jan. de 1995). «Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA». Nature (ENGLAND) 373 (6511): 257–61. doi:10.1038/373257a0. ISSN 0028-0836. PMID 7816143. 
  14. a b Yang, X; Chen Y, Gabuzda D (Sep. de 1999). «ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB». J. Biol. Chem. (UNITED STATES) 274 (39): 27981–8. ISSN 0021-9258. PMID 10488148. 
  15. Nomura, N; Zu Y L, Maekawa T, Tabata S, Akiyama T, Ishii S (Feb. de 1993). «Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1». J. Biol. Chem. (UNITED STATES) 268 (6): 4259–66. ISSN 0021-9258. PMID 8440710. 
  16. Finkel, T; Duc J, Fearon E R, Dang C V, Tomaselli G F (Jan. de 1993). «Detection and modulation in vivo of helix-loop-helix protein-protein interactions». J. Biol. Chem. (UNITED STATES) 268 (1): 5–8. ISSN 0021-9258. PMID 8380166. 
  17. a b c Venugopal, R; Jaiswal A K (Dec. de 1998). «Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes». Oncogene (ENGLAND) 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. ISSN 0950-9232. PMID 9872330. 
  18. Westermarck, Jukka; Weiss Carsten, Saffrich Rainer, Kast Jürgen, Musti Anna-Maria, Wessely Matthias, Ansorge Wilhelm, Séraphin Bertrand, Wilm Matthias, Valdez Benigno C, Bohmann Dirk (Feb. de 2002). «The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription». EMBO J. (England) 21 (3): 451–60. ISSN 0261-4189. PMID 11823437. 
  19. a b Franklin, C C; McCulloch A V, Kraft A S (Feb. de 1995). «In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB». Biochem. J. (ENGLAND). 305 ( Pt 3): 967–74. ISSN 0264-6021. PMID 7848298. 
  20. Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. de 2003). «Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling». EMBO J. (England) 22 (23): 6277–88. doi:10.1093/emboj/cdg605. ISSN 0261-4189. PMID 14633987. 
  21. Nishitoh, H; Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (Sep. de 1998). «ASK1 is essential for JNK/SAPK activation by TRAF2». Mol. Cell (UNITED STATES) 2 (3): 389–95. ISSN 1097-2765. PMID 9774977. 
  22. Dérijard, B; Hibi M, Wu I H, Barrett T, Su B, Deng T, Karin M, Davis R J (Mar. de 1994). «JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain». Cell (UNITED STATES) 76 (6): 1025–37. ISSN 0092-8674. PMID 8137421. 
  23. Yazgan, Oya; Pfarr Curt M (Aug. de 2002). «Regulation of two JunD isoforms by Jun N-terminal kinases». J. Biol. Chem. (United States) 277 (33): 29710–8. doi:10.1074/jbc.M204552200. ISSN 0021-9258. PMID 12052834. 
  24. Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (Sep. de 2001). «Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death». J. Biol. Chem. (United States) 276 (39): 36530–4. doi:10.1074/jbc.M104837200. ISSN 0021-9258. PMID 11479302. 
  25. Meyer, C F; Wang X, Chang C, Templeton D, Tan T H (Apr. de 1996). «Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation». J. Biol. Chem. (UNITED STATES) 271 (15): 8971–6. ISSN 0021-9258. PMID 8621542. 
  26. Cano, E; Hazzalin C A, Kardalinou E, Buckle R S, Mahadevan L C (Nov. de 1995). «Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction». J. Cell. Sci. (ENGLAND). 108 ( Pt 11): 3599–609. ISSN 0021-9533. PMID 8586671. 
  27. Tournier, C; Whitmarsh A J, Cavanagh J, Barrett T, Davis R J (Jul. de 1997). «Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (14): 7337–42. ISSN 0027-8424. PMID 9207092. 
  28. Lee, S K; Kim J H, Lee Y C, Cheong J, Lee J W (Apr. de 2000). «Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor». J. Biol. Chem. (UNITED STATES) 275 (17): 12470–4. ISSN 0021-9258. PMID 10777532. 
  29. Wertz, Ingrid E; O'Rourke Karen M, Zhang Zemin, Dornan David, Arnott David, Deshaies Raymond J, Dixit Vishva M (Feb. de 2004). «Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase». Science (United States) 303 (5662): 1371–4. doi:10.1126/science.1093549. PMID 14739464. 
  30. Bianchi, Elisabetta; Denti Simona, Catena Raffaella, Rossetti Grazisa, Polo Simona, Gasparian Sona, Putignano Stella, Rogge Lars, Pardi Ruggero (May. de 2003). «Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity». J. Biol. Chem. (United States) 278 (22): 19682–90. doi:10.1074/jbc.M212681200. ISSN 0021-9258. PMID 12615916. 
  31. Wulf, G M; Ryo A, Wulf G G, Lee S W, Niu T, Petkova V, Lu K P (Jul. de 2001). «Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1». EMBO J. (England) 20 (13): 3459–72. doi:10.1093/emboj/20.13.3459. ISSN 0261-4189. PMID 11432833. 
  32. Zhang, Y; Feng X H, Derynck R (Aug. de 1998). «Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription». Nature (ENGLAND) 394 (6696): 909–13. doi:10.1038/29814. ISSN 0028-0836. PMID 9732876. 
  33. Verrecchia, F; Pessah M, Atfi A, Mauviel A (Sep. de 2000). «Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation». J. Biol. Chem. (UNITED STATES) 275 (39): 30226–31. doi:10.1074/jbc.M005310200. ISSN 0021-9258. PMID 10903323. 
  34. Liberati, N T; Datto M B, Frederick J P, Shen X, Wong C, Rougier-Chapman E M, Wang X F (Apr. de 1999). «Smads bind directly to the Jun family of AP-1 transcription factors». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4844–9. ISSN 0027-8424. PMID 10220381. 
  35. Jung, Dong-Ju; Sung Hee-Sook, Goo Young-Wha, Lee Hyun Mi, Park Ok Ku, Jung Sung-Yun, Lim Janghoo, Kim Han-Jong, Lee Soo-Kyung, Kim Tae Sung, Lee Jae Woon, Lee Young Chul (Jul. de 2002). «Novel transcription coactivator complex containing activating signal cointegrator 1». Mol. Cell. Biol. (United States) 22 (14): 5203–11. ISSN 0270-7306. PMID 12077347. 
  36. a b Yamaguchi, Y; Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H (Aug. de 1998). «Casein kinase II interacts with the bZIP domains of several transcription factors». Nucleic Acids Res. (ENGLAND) 26 (16): 3854–61. ISSN 0305-1048. PMID 9685505. 
  37. a b Zhang, X; Wrzeszczynska M H, Horvath C M, Darnell J E (Oct. de 1999). «Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation». Mol. Cell. Biol. (UNITED STATES) 19 (10): 7138–46. ISSN 0270-7306. PMID 10490649. 
  38. Vasanwala, Farha H; Kusam Saritha, Toney Lisa M, Dent Alexander L (Aug. de 2002). «Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene». J. Immunol. (United States) 169 (4): 1922–9. ISSN 0022-1767. PMID 12165517. 
  39. Na, S Y; Choi J E, Kim H J, Jhun B H, Lee Y C, Lee J W (Oct. de 1999). «Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation». J. Biol. Chem. (UNITED STATES) 274 (40): 28491–6. ISSN 0021-9258. PMID 10497212. 
  40. Sato, N; Sadar M D, Bruchovsky N, Saatcioglu F, Rennie P S, Sato S, Lange P H, Gleave M E (Jul. de 1997). «Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP». J. Biol. Chem. (UNITED STATES) 272 (28): 17485–94. ISSN 0021-9258. PMID 9211894. 
  41. Basuyaux, J P; Ferreira E, Stéhelin D, Butticè G (Oct. de 1997). «The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner». J. Biol. Chem. (UNITED STATES) 272 (42): 26188–95. ISSN 0021-9258. PMID 9334186. 
  42. Pearson, Andree G; Gray Carol W, Pearson John F, Greenwood Jeffrey M, During Matthew J, Dragunow Michael (Dec. de 2003). «ATF3 enhances c-Jun-mediated neurite sprouting». Brain Res. Mol. Brain Res. (Netherlands) 120 (1): 38–45. ISSN 0169-328X. PMID 14667575. 
  43. Chen, B P; Wolfgang C D, Hai T (Mar. de 1996). «Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10». Mol. Cell. Biol. (UNITED STATES) 16 (3): 1157–68. ISSN 0270-7306. PMID 8622660. 
  44. Moreau, A; Yotov W V, Glorieux F H, St-Arnaud R (Mar. de 1998). «Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription». Mol. Cell. Biol. (UNITED STATES) 18 (3): 1312–21. ISSN 0270-7306. PMID 9488446. 
  45. Claret, F X; Hibi M, Dhut S, Toda T, Karin M (Oct. de 1996). «A new group of conserved coactivators that increase the specificity of AP-1 transcription factors». Nature (ENGLAND) 383 (6599): 453–7. doi:10.1038/383453a0. ISSN 0028-0836. PMID 8837781. 
  46. Ubeda, M; Vallejo M, Habener J F (Nov. de 1999). «CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins». Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589–99. ISSN 0270-7306. PMID 10523647. 
  47. Jung, Dong-Ju; Na Soon-Young, Na Doe Sun, Lee Jae Woon (Jan. de 2002). «Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors». J. Biol. Chem. (United States) 277 (2): 1229–34. doi:10.1074/jbc.M110417200. ISSN 0021-9258. PMID 11704680. 
  48. Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. de 1999). «A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo». J. Biol. Chem. (UNITED STATES) 274 (48): 34283–93. ISSN 0021-9258. PMID 10567404. 
  49. Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. de 2000). «Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2». Mol. Endocrinol. (UNITED STATES) 14 (6): 915–25. ISSN 0888-8809. PMID 10847592. 
  50. Lee, S K; Kim H J, Na S Y, Kim T S, Choi H S, Im S Y, Lee J W (Jul. de 1998). «Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits». J. Biol. Chem. (UNITED STATES) 273 (27): 16651–4. ISSN 0021-9258. PMID 9642216. 
  51. Bengal, E; Ransone L, Scharfmann R, Dwarki V J, Tapscott S J, Weintraub H, Verma I M (Feb. de 1992). «Functional antagonism between c-Jun and MyoD proteins: a direct physical association». Cell (UNITED STATES) 68 (3): 507–19. ISSN 0092-8674. PMID 1310896. 
  52. a b Hess, J; Porte D, Munz C, Angel P (Jun. de 2001). «AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element». J. Biol. Chem. (United States) 276 (23): 20029–38. doi:10.1074/jbc.M010601200. ISSN 0021-9258. PMID 11274169. 
  53. a b D'Alonzo, Richard C; Selvamurugan Nagarajan, Karsenty Gerard, Partridge Nicola C (Jan. de 2002). «Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation». J. Biol. Chem. (United States) 277 (1): 816–22. doi:10.1074/jbc.M107082200. ISSN 0021-9258. PMID 11641401. 

Véase también[editar]

Enlaces externos[editar]