Factor de transcripción AP-1

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Complejo AP-1/ADN. Estructura cristalográfica de un heterodímero compuesto por c-Fos (azul) y c-Jun (verde) unido al ADN (marrón).

En el campo de la biología molecular, la proteína activadora 1 (AP-1) es un factor de transcripción heterodimérico compuesto por proteínas pertenecientes a las familias de c-Fos, c-Jun, ATF y JDP. Está implicada en la regulación de la expresión de genes relacionados con la respuesta a diversos estímulos, como citoquinas, factores de crecimiento, estrés e infecciones virales o bacterianas. AP-1 controla, de este modo, diversos procesos celulares incluyendo diferenciación, proliferación y apoptosis.

AP-1 presenta la capacidad de activar la transcripción de los genes que contienen elementos de respuesta a 12-O-tetradecanoilforbol-13-acetato (TPA), caracterizados por la secuencia 5'-TGAG/CTCA-3'.[1] AP-1 se une al ADN por medio de una región de su secuencia rica en aminoácidos básicos, mientras que la estructura dimérica está formada por una cremallera de leucina.[2]


Activa a AMPc,[3] IL-2,[4] CREB,[5] WEE1,[6] OPN,[7] RD,[8] MMP,[9] calpaína-2,[9] quinasas dependientes de ciclinas G1,[10] BMP-4,[11] receptor H1,[12] ciclina D1,[12] GC-A,[13] TGF-b,[14] NOTCH4,[15] Blimp-1,[16] FasL,[cita requerida] TNF-a,[cita requerida] c-jun,[17] Bcl-xl,[18] ECs,[19] miR-21,[20] Cox-2,[21] PtdIns(3,5)P2,[22] factor tisular,[23] HMG-I/Y,[24] PTH (rP),[25] elementos de respuesta a TPA,[26] proteína Gap-43,[27] hMT IIA,[28] TGF-B1,[29] IL-8,[30] IL-4,[31] IL-5,[31] GM-CSF,[31] hGSTP1,[32] Egr-1,[33] fibronectina,[34]
Inhibe a PAI-1,[35] Colágeno,[36] HNF-1,[37] Osteocalcina,[38]
Activada por PDTC,[39] IE1,[40] JNK,[41] RIP2,[42] TPA,[43] PDCD4,[44] KSHV,[45] MAPK,[46] Serralisina,[47] PRL,[48] K15,[49] ácido lipoico,[50] éster de forbol,[51] Citoquina,[52]
Inhibida por MIF,[53] BATF


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  25. General Introduction
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  38. Retinoic Acid Inhibits Serum-stimulated Activator Protein-1 via ...
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  50. Erase Your Ugly Scars
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