Receptor X retinoide alfa

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Receptor X retinoide alfa

Estructura tridimensional del receptor RXRA.
Estructuras disponibles
PDB Búsqueda en Human Uniprot: PDBeRCSB
Identificadores
Símbolo RXRA (HUGO: 10477);
Identificadores externos OMIM180245 GeneCardsGen RXRA
Locus Cr. 9 q34
Ortología
Especies Humano Ratón
Entrez 6256 n/a
UniProt P19793 n/a
RefSeq (mRNA) NM_002957 n/a

El receptor X retinoide alfa (RXRA), también conocido como NR2B1 (de sus siglas en inglés "nuclear receptor subfamily 2, group B, member 1"), es un receptor nuclear codificado, en humanos, por el gen rxrA.[1]

Los receptores X retinoides (RXRs) y los receptores de ácido retinoico (RARs) son receptores nucleares que actúan como intermediarios de los efectos biológicos de los retinoides en la activación del gen que codifica las proteínas implicadas en la síntesis de ácido retinoico. Estos receptores ejercen su acción mediante la unión, como homodímeros o como heterodímeros, a secuencias específicas en los promotores de los genes diana, y la regulación de su transcripción. La proteína RXRA es un miembro de la superfamilia de factores de transcripción de receptores de hormonas tiroideas y esteroideas.[2]

Interacciones[editar]

El receptor X retinoide alfa ha demostrado ser capaz de interaccionar con:

Véase también[editar]

Referencias[editar]

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  2. «Entrez Gene: RXRA retinoid X receptor, alpha».
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  4. a b McNamara, P; Seo S B, Rudic R D, Sehgal A, Chakravarti D, FitzGerald G A (Jun. 2001). «Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock». Cell (United States) 105 (7):  pp. 877–89. ISSN 0092-8674. PMID 11439184. 
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  6. a b c Lee, Wen-yi; Noy Noa (Feb. 2002). «Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain». Biochemistry (United States) 41 (8):  pp. 2500–8. ISSN 0006-2960. PMID 11851396. 
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  20. Kong, Hee Jeong; Park Min Jung, Hong SunHwa, Yu Hyun Jung, Lee Young Chul, Choi Young Hyun, Cheong JaeHun (Nov. 2003). «Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2». Hepatology (United States) 38 (5):  pp. 1258–66. doi:10.1053/jhep.2003.50451. ISSN 0270-9139. PMID 14578865. 
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