POU2F1

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Factor de transcripción 1 clase 2 con dominio POU

Estructura tridimensional de la proteína POU2F1.
Estructuras disponibles
PDB Búsqueda en Human Uniprot: PDBeRCSB
Identificadores
Símbolos POU2F1 (HUGO: 9212); OCT1; OTF1
Identificadores externos OMIM164175 GeneCardsGen POU2F1
Locus Cr. 1 q24.1-q24.2
Ortología
Especies Humano Ratón
Entrez 5451 n/a
UniProt P14859 n/a
RefSeq (mRNA) NP_002688 n/a

El factor de transcripción 1 clase 2 con dominio POU (POU2F1) es una proteína codificada en humanos por el gen POU2F1.[1] [2]

Interacciones[editar]

La proteína POU2F1 ha demostrado ser capaz de interaccionar con:

Véase también[editar]

Referencias[editar]

  1. Roberts SB, Segil N, Heintz N (Oct 1991). «Differential phosphorylation of the transcription factor Oct1 during the cell cycle». Science 253 (5023):  pp. 1022–6. PMID 1887216. 
  2. «Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1».
  3. Hovde, Stacy; Brooks Aimee, Strong Katie, Geiger James H (Mar. 2002). «Crystallization of the Oct-1/SNAP190 peptide/DNA complex». Acta Crystallogr. D Biol. Crystallogr. (Denmark) 58 (Pt 3):  pp. 511–2. ISSN 0907-4449. PMID 11856838. 
  4. a b Wong, M W; Henry R W, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (Jan. 1998). «The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1». Mol. Cell. Biol. (UNITED STATES) 18 (1):  pp. 368–77. ISSN 0270-7306. PMID 9418884. 
  5. Schild-Poulter, C; Pope L, Giffin W, Kochan J C, Ngsee J K, Traykova-Andonova M, Haché R J (May. 2001). «The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase». J. Biol. Chem. (United States) 276 (20):  pp. 16848–56. doi:10.1074/jbc.M100768200. ISSN 0021-9258. PMID 11279128. 
  6. Matheos, Diamanto; Ruiz Marcia T, Price Gerald B, Zannis-Hadjopoulos Maria (Oct. 2002). «Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication». Biochim. Biophys. Acta (Netherlands) 1578 (1-3):  pp. 59–72. ISSN 0006-3002. PMID 12393188. 
  7. a b Préfontaine, G G; Walther R, Giffin W, Lemieux M E, Pope L, Haché R J (Sep. 1999). «Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter». J. Biol. Chem. (UNITED STATES) 274 (38):  pp. 26713–9. ISSN 0021-9258. PMID 10480874. 
  8. Wang, J M; Préfontaine G G, Lemieux M E, Pope L, Akimenko M A, Haché R J (Oct. 1999). «Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding». Mol. Cell. Biol. (UNITED STATES) 19 (10):  pp. 7106–22. ISSN 0270-7306. PMID 10490647. 
  9. Préfontaine, G G; Lemieux M E, Giffin W, Schild-Poulter C, Pope L, LaCasse E, Walker P, Haché R J (Jun. 1998). «Recruitment of octamer transcription factors to DNA by glucocorticoid receptor». Mol. Cell. Biol. (UNITED STATES) 18 (6):  pp. 3416–30. ISSN 0270-7306. PMID 9584182. 
  10. Ström, A C; Forsberg M, Lillhager P, Westin G (Jun. 1996). «The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression». Nucleic Acids Res. (ENGLAND) 24 (11):  pp. 1981–6. ISSN 0305-1048. PMID 8668525. 
  11. Gunther, M; Laithier M, Brison O (Jul. 2000). «A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening». Mol. Cell. Biochem. (NETHERLANDS) 210 (1-2):  pp. 131–42. ISSN 0300-8177. PMID 10976766. 
  12. a b Zheng, Lei; Roeder Robert G, Luo Yan (Jul. 2003). «S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component». Cell (United States) 114 (2):  pp. 255–66. ISSN 0092-8674. PMID 12887915. 
  13. Chasman, D; Cepek K, Sharp P A, Pabo C O (Oct. 1999). «Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface». Genes Dev. (UNITED STATES) 13 (20):  pp. 2650–7. ISSN 0890-9369. PMID 10541551. 
  14. Lee, L; Stollar E, Chang J, Grossmann J G, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (Jun. 2001). «Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator». Biochemistry (United States) 40 (22):  pp. 6580–8. ISSN 0006-2960. PMID 11380252. 
  15. La Boissière, S; Hughes T, O'Hare P (Jan. 1999). «HCF-dependent nuclear import of VP16». EMBO J. (ENGLAND) 18 (2):  pp. 480–9. doi:10.1093/emboj/18.2.480. ISSN 0261-4189. PMID 9889203. 
  16. Kristie, T M; Sharp P A (Mar. 1993). «Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)». J. Biol. Chem. (UNITED STATES) 268 (9):  pp. 6525–34. ISSN 0021-9258. PMID 8454622. 
  17. Zwilling, S; Annweiler A, Wirth T (May. 1994). «The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP». Nucleic Acids Res. (ENGLAND) 22 (9):  pp. 1655–62. ISSN 0305-1048. PMID 8202368. 
  18. van Heel, David A; Udalova Irina A, De Silva Arjuna P, McGovern Dermot P, Kinouchi Yoshitaka, Hull Jeremy, Lench Nicholas J, Cardon Lon R, Carey Alisoun H, Jewell Derek P, Kwiatkowski Dominic (May. 2002). «Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors». Hum. Mol. Genet. (England) 11 (11):  pp. 1281–9. ISSN 0964-6906. PMID 12019209. 
  19. Kakizawa, T; Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J, Kumagai M, Yamashita K, Hashizume K (Mar. 2001). «Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor». J. Biol. Chem. (United States) 276 (13):  pp. 9720–5. doi:10.1074/jbc.M008531200. ISSN 0021-9258. PMID 11134019. 
  20. Nie, J; Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T (Mar. 1998). «Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase». FEBS Lett. (NETHERLANDS) 424 (1-2):  pp. 27–32. ISSN 0014-5793. PMID 9537509. 
  21. Inamoto, S; Segil N, Pan Z Q, Kimura M, Roeder R G (Nov. 1997). «The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors». J. Biol. Chem. (UNITED STATES) 272 (47):  pp. 29852–8. ISSN 0021-9258. PMID 9368058. 
  22. Kakizawa, T; Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, Mori J i, Kumagai M, Hashizume K (Jul. 1999). «Functional interaction between Oct-1 and retinoid X receptor». J. Biol. Chem. (UNITED STATES) 274 (27):  pp. 19103–8. ISSN 0021-9258. PMID 10383413. 

Enlaces externos[editar]