NCOA6

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Coactivador 6 de receptores nucleares
Identificadores
Símbolos NCOA6 (HUGO: 15936); HOXA7, ANTP, HOX1.1, PRIP, TRBP, AIB3, ASC2, KIAA0181, NRC, RAP250
Identificadores externos OMIM605299 GeneCardsGen NCOA6
Locus Cr. 20 q11.22
Ortología
Especies Humano Ratón
Entrez 23054 n/a
UniProt Q14686 n/a
RefSeq (mRNA) NP_054790 n/a

NCOA6 (de sus siglas en inglés Nuclear receptor coactivator 6) es una proteína codificada en humanos por el gen ncoa6.[1] [2] [3] Esta proteína es un coactivador transcripcional que puede interaccionar con receptores nucleares de hormonas para potenciar sus respectivas funciones de activadores transcripcionales. Diversos estudios han demostrado que NCOA6 está implicada en la coactivación dependiente de hormona de diversos receptores, entre los que cabe incluir receptores de prostanoides, de retinoides, de vitamina D3, de hormona tiroidea y de esteroides. NCOA6 podría actuar también como un coactivador general, como pone de manifiesto el hecho de que muestre la capacidad de interaccionar con algunos factores de transcripción constitutivos como las histona acetiltransferasas y las histona metiltransferasas.[3]

Interacciones[editar]

La proteína NCOA6 ha demostrado ser capaz de interaccionar con:

Véase también[editar]

Referencias[editar]

  1. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). «Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1». DNA Res 3 (1):  pp. 17–24. PMID 8724849. 
  2. Estey A, Kemp M, Allison S, Lamb C (Jan 1994). «Evaluation of a patient information booklet». J Nurs Staff Dev 9 (6):  pp. 278–82. PMID 8263591. 
  3. a b «Entrez Gene: NCOA6 nuclear receptor coactivator 6».
  4. a b c d e f Ko, L; Cardona G R, Chin W W (May. 2000). «Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (11):  pp. 6212–7. ISSN 0027-8424. PMID 10823961. 
  5. a b Ko, Lan; Chin William W (Mar. 2003). «Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase». J. Biol. Chem. (United States) 278 (13):  pp. 11471–9. doi:10.1074/jbc.M209723200. ISSN 0021-9258. PMID 12519782. 
  6. a b c d e f g Goo, Young-Hwa; Sohn Young Chang, Kim Dae-Hwan, Kim Seung-Whan, Kang Min-Jung, Jung Dong-Ju, Kwak Eunyee, Barlev Nickolai A, Berger Shelley L, Chow Vincent T, Roeder Robert G, Azorsa David O, Meltzer Paul S, Suh Pan-Gil, Song Eun Joo, Lee Kong-Joo, Lee Young Chul, Lee Jae Woon (Jan. 2003). «Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins». Mol. Cell. Biol. (United States) 23 (1):  pp. 140–9. ISSN 0270-7306. PMID 12482968. 
  7. Kong, Hee Jeong; Yu Hyun Jung, Hong SunHwa, Park Min Jung, Choi Young Hyun, An Won Gun, Lee Jae Woon, Cheong JaeHun (Nov. 2003). «Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation». Mol. Cancer Res. (United States) 1 (13):  pp. 948–58. ISSN 1541-7786. PMID 14638867. 
  8. a b Goo, Young-Hwa; Na Soon-Young, Zhang Hao, Xu Jianming, Hong SunHwa, Cheong JaeHun, Lee Soo-Kyung, Lee Jae Woon (Feb. 2004). «Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation». J. Biol. Chem. (United States) 279 (8):  pp. 7131–5. doi:10.1074/jbc.M312563200. ISSN 0021-9258. PMID 14645241. 
  9. a b c d e f g Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. 1999). «A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo». J. Biol. Chem. (UNITED STATES) 274 (48):  pp. 34283–93. ISSN 0021-9258. PMID 10567404. 
  10. a b c d e f g Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (Feb. 2001). «Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2». Mol. Endocrinol. (United States) 15 (2):  pp. 241–54. ISSN 0888-8809. PMID 11158331. 
  11. Hong, SunHwa; Choi Hyun Mi, Park Min Jung, Kim Young Hee, Choi Yoon Ha, Kim Hyung Hoi, Choi Young Hyun, Cheong JaeHun (Apr. 2004). «Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid». J. Biol. Chem. (United States) 279 (17):  pp. 16996–7003. doi:10.1074/jbc.M311752200. ISSN 0021-9258. PMID 14734562. 
  12. Hong, SunHwa; Kim Sun Hee, Heo Mi Ae, Choi Yoon Ha, Park Min Jung, Yoo Mi Ae, Kim Han Do, Kang Ho Sung, Cheong JaeHun (Feb. 2004). «Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock». FEBS Lett. (Netherlands) 559 (1-3):  pp. 165–70. doi:10.1016/S0014-5793(04)00028-6. ISSN 0014-5793. PMID 14960326. 
  13. a b Kong, Hee Jeong; Park Min Jung, Hong SunHwa, Yu Hyun Jung, Lee Young Chul, Choi Young Hyun, Cheong JaeHun (Nov. 2003). «Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2». Hepatology (United States) 38 (5):  pp. 1258–66. doi:10.1053/jhep.2003.50451. ISSN 0270-9139. PMID 14578865. 
  14. Misra, Parimal; Qi Chao, Yu Songtao, Shah Sejal H, Cao Wen-Qing, Rao M Sambasiva, Thimmapaya Bayar, Zhu Yijun, Reddy Janardan K (May. 2002). «Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation». J. Biol. Chem. (United States) 277 (22):  pp. 20011–9. doi:10.1074/jbc.M201739200. ISSN 0021-9258. PMID 11912212. 
  15. Zhu, Y; Qi C, Cao W Q, Yeldandi A V, Rao M S, Reddy J K (Aug. 2001). «Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (18):  pp. 10380–5. doi:10.1073/pnas.181347498. ISSN 0027-8424. PMID 11517327. 
  16. a b c d Ko, Lan; Cardona Guemalli R, Iwasaki Toshiharu, Bramlett Kelli S, Burris Thomas P, Chin William W (Jan. 2002). «Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs». Mol. Endocrinol. (United States) 16 (1):  pp. 128–40. ISSN 0888-8809. PMID 11773444. 
  17. a b Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. 2000). «Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2». Mol. Endocrinol. (UNITED STATES) 14 (6):  pp. 915–25. ISSN 0888-8809. PMID 10847592. 

Enlaces externos[editar]