Receptor de TGF-beta 1

Receptor del factor de crecimiento transformante beta 1
	; Estructura tridimensional del receptor de TGF-beta 1.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1b6c
Identificadores
Símbolos	TGFBR1 (HGNC: 11772) ACVRLK4, AAT5, ALK-5, ALK5, SKR4, TGFR-1
Identificadores; externos	OMIM: 190181 ; EBI: TGFBR1; GeneCards: Gen TGFBR1; UniProt: TGFBR1;
Locus	Cr. 9 q22.33
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
7046
P36897	n/a
NP_004603	n/a
	v; t; e;
	[editar datos en Wikidata]

El receptor del factor de crecimiento transformante beta 1 (TGFBR1) es un receptor de TGF-beta codificado en humanos por el gen HGNC TGFBR1 , corresponde a la actividad enzimática EC 2.7.11.30

Este receptor de TGF-beta 1 forma un complejo heterodimérico con el receptor de TGF-beta 2 cuando se encuentra unido al TGF-beta, transduciendo la señal desde la superficie celular al citoplasma. Este receptor posee actividad serina/treonina proteína cinasa. Se han asociado mutaciones de este gen con el síndrome de Loeys-Dietz (LDAS).^[1]

Interacciones

El receptor de TGF-beta 1 ha demostrado ser capaz de interaccionar con:

Véase también

Referencias

↑ «Entrez Gene: TGFBR1 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)».
↑ Mochizuki, Toshiaki; Miyazaki Hideyo, Hara Takane, Furuya Toshio, Imamura Takeshi, Watabe Tetsuro, Miyazono Kohei (Jul. de 2004). «Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling». J. Biol. Chem. (United States) 279 (30): 31568-74. ISSN 0021-9258. PMID 15148321. doi:10.1074/jbc.M313977200.
↑ Asano, Yoshihide; Ihn Hironobu, Yamane Kenichi, Kubo Masahide, Tamaki Kunihiko (Jan. de 2004). «Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts». J. Clin. Invest. (United States) 113 (2): 253-64. ISSN 0021-9738. PMID 14722617. doi:10.1172/JCI16269.
↑ Koinuma, Daizo; Shinozaki Masahiko, Komuro Akiyoshi, Goto Kouichiro, Saitoh Masao, Hanyu Aki, Ebina Masahito, Nukiwa Toshihiro, Miyazawa Keiji, Imamura Takeshi, Miyazono Kohei (Dec. de 2003). «Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7». EMBO J. (England) 22 (24): 6458-70. ISSN 0261-4189. PMID 14657019. doi:10.1093/emboj/cdg632.
↑ Kavsak, P; Rasmussen R K, Causing C G, Bonni S, Zhu H, Thomsen G H, Wrana J L (Dec. de 2000). «Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation». Mol. Cell (United States) 6 (6): 1365-75. ISSN 1097-2765. PMID 11163210.
↑ Hayashi, H; Abdollah S, Qiu Y, Cai J, Xu Y Y, Grinnell B W, Richardson M A, Topper J N, Gimbrone M A, Wrana J L, Falb D (Jun. de 1997). «The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling». Cell (UNITED STATES) 89 (7): 1165-73. ISSN 0092-8674. PMID 9215638.
↑ ^a ^b Datta, P K; Moses H L (mayo. de 2000). «STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling». Mol. Cell. Biol. (UNITED STATES) 20 (9): 3157-67. ISSN 0270-7306. PMID 10757800.
↑ Wang, T; Donahoe P K, Zervos A S (Jul. de 1994). «Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12». Science (UNITED STATES) 265 (5172): 674-6. ISSN 0036-8075. PMID 7518616.
↑ Liu, F; Ventura F, Doody J, Massagué J (Jul. de 1995). «Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs». Mol. Cell. Biol. (UNITED STATES) 15 (7): 3479-86. ISSN 0270-7306. PMID 7791754.
↑ Ebner, R; Chen R H, Lawler S, Zioncheck T, Derynck R (Nov. de 1993). «Determination of type I receptor specificity by the type II receptors for TGF-beta or activin». Science (UNITED STATES) 262 (5135): 900-2. ISSN 0036-8075. PMID 8235612.
↑ Oh, S P; Seki T, Goss K A, Imamura T, Yi Y, Donahoe P K, Li L, Miyazono K, ten Dijke P, Kim S, Li E (Mar. de 2000). «Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (6): 2626-31. ISSN 0027-8424. PMID 10716993.
↑ ^a ^b Razani, B; Zhang X L, Bitzer M, von Gersdorff G, Böttinger E P, Lisanti M P (Mar. de 2001). «Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor». J. Biol. Chem. (United States) 276 (9): 6727-38. ISSN 0021-9258. PMID 11102446. doi:10.1074/jbc.M008340200.
↑ Kawabata, M; Imamura T, Miyazono K, Engel M E, Moses H L (Dec. de 1995). «Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha». J. Biol. Chem. (UNITED STATES) 270 (50): 29628-31. ISSN 0021-9258. PMID 8530343.
↑ Griswold-Prenner, I; Kamibayashi C, Maruoka E M, Mumby M C, Derynck R (Nov. de 1998). «Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A». Mol. Cell. Biol. (UNITED STATES) 18 (11): 6595-604. ISSN 0270-7306. PMID 9774674.
↑ Kawabata, M; Chytil A, Moses H L (Mar. de 1995). «Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor». J. Biol. Chem. (UNITED STATES) 270 (10): 5625-30. ISSN 0021-9258. PMID 7890683.
↑ Guerrero-Esteo, Mercedes; Sanchez-Elsner Tilman, Letamendia Ainhoa, Bernabeu Carmelo (Aug. de 2002). «Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II». J. Biol. Chem. (United States) 277 (32): 29197-209. ISSN 0021-9258. PMID 12015308. doi:10.1074/jbc.M111991200.
↑ Barbara, N P; Wrana J L, Letarte M (Jan. de 1999). «Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily». J. Biol. Chem. (UNITED STATES) 274 (2): 584-94. ISSN 0021-9258. PMID 9872992.
↑ Wrighton, Katharine H; Lin Xia, Feng Xin-Hua (Jul. de 2008). «Critical regulation of TGFbeta signaling by Hsp90». Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (27): 9244-9. PMID 18591668. doi:10.1073/pnas.0800163105.
↑ Datta, P K; Chytil A, Gorska A E, Moses H L (Dec. de 1998). «Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling». J. Biol. Chem. (UNITED STATES) 273 (52): 34671-4. ISSN 0021-9258. PMID 9856985.

Lecturas complementarias

Massagué J (1992). «Receptors for the TGF-beta family.». Cell 69 (7): 1067-70. PMID 1319842. doi:10.1016/0092-8674(92)90627-O.
Wrana JL (1998). «TGF-beta receptors and signalling mechanisms.». Mineral and electrolyte metabolism 24 (2-3): 120-30. PMID 9525694. doi:10.1159/000057359.
Josso N, di Clemente N, Gouédard L (2001). «Anti-Müllerian hormone and its receptors.». Mol. Cell. Endocrinol. 179 (1-2): 25-32. PMID 11420127. doi:10.1016/S0303-7207(01)00467-1.

Datos: Q14911572

[1] «Entrez Gene: TGFBR1 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)».

[pmid15148321-2] Mochizuki, Toshiaki; Miyazaki Hideyo, Hara Takane, Furuya Toshio, Imamura Takeshi, Watabe Tetsuro, Miyazono Kohei (Jul. de 2004). «Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling». J. Biol. Chem. (United States) 279 (30): 31568-74. ISSN 0021-9258. PMID 15148321. doi:10.1074/jbc.M313977200.

[pmid14722617-3] Asano, Yoshihide; Ihn Hironobu, Yamane Kenichi, Kubo Masahide, Tamaki Kunihiko (Jan. de 2004). «Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts». J. Clin. Invest. (United States) 113 (2): 253-64. ISSN 0021-9738. PMID 14722617. doi:10.1172/JCI16269.

[pmid14657019-4] Koinuma, Daizo; Shinozaki Masahiko, Komuro Akiyoshi, Goto Kouichiro, Saitoh Masao, Hanyu Aki, Ebina Masahito, Nukiwa Toshihiro, Miyazawa Keiji, Imamura Takeshi, Miyazono Kohei (Dec. de 2003). «Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7». EMBO J. (England) 22 (24): 6458-70. ISSN 0261-4189. PMID 14657019. doi:10.1093/emboj/cdg632.

[pmid11163210-5] Kavsak, P; Rasmussen R K, Causing C G, Bonni S, Zhu H, Thomsen G H, Wrana J L (Dec. de 2000). «Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation». Mol. Cell (United States) 6 (6): 1365-75. ISSN 1097-2765. PMID 11163210.

[pmid9215638-6] Hayashi, H; Abdollah S, Qiu Y, Cai J, Xu Y Y, Grinnell B W, Richardson M A, Topper J N, Gimbrone M A, Wrana J L, Falb D (Jun. de 1997). «The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling». Cell (UNITED STATES) 89 (7): 1165-73. ISSN 0092-8674. PMID 9215638.

[pmid10757800-7] Datta, P K; Moses H L (mayo. de 2000). «STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling». Mol. Cell. Biol. (UNITED STATES) 20 (9): 3157-67. ISSN 0270-7306. PMID 10757800.

[pmid7518616-8] Wang, T; Donahoe P K, Zervos A S (Jul. de 1994). «Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12». Science (UNITED STATES) 265 (5172): 674-6. ISSN 0036-8075. PMID 7518616.

[pmid7791754-9] Liu, F; Ventura F, Doody J, Massagué J (Jul. de 1995). «Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs». Mol. Cell. Biol. (UNITED STATES) 15 (7): 3479-86. ISSN 0270-7306. PMID 7791754.

[pmid8235612-10] Ebner, R; Chen R H, Lawler S, Zioncheck T, Derynck R (Nov. de 1993). «Determination of type I receptor specificity by the type II receptors for TGF-beta or activin». Science (UNITED STATES) 262 (5135): 900-2. ISSN 0036-8075. PMID 8235612.

[pmid10716993-11] Oh, S P; Seki T, Goss K A, Imamura T, Yi Y, Donahoe P K, Li L, Miyazono K, ten Dijke P, Kim S, Li E (Mar. de 2000). «Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (6): 2626-31. ISSN 0027-8424. PMID 10716993.

[pmid11102446-12] Razani, B; Zhang X L, Bitzer M, von Gersdorff G, Böttinger E P, Lisanti M P (Mar. de 2001). «Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor». J. Biol. Chem. (United States) 276 (9): 6727-38. ISSN 0021-9258. PMID 11102446. doi:10.1074/jbc.M008340200.

[pmid8530343-13] Kawabata, M; Imamura T, Miyazono K, Engel M E, Moses H L (Dec. de 1995). «Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha». J. Biol. Chem. (UNITED STATES) 270 (50): 29628-31. ISSN 0021-9258. PMID 8530343.

[pmid9774674-14] Griswold-Prenner, I; Kamibayashi C, Maruoka E M, Mumby M C, Derynck R (Nov. de 1998). «Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A». Mol. Cell. Biol. (UNITED STATES) 18 (11): 6595-604. ISSN 0270-7306. PMID 9774674.

[pmid7890683-15] Kawabata, M; Chytil A, Moses H L (Mar. de 1995). «Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor». J. Biol. Chem. (UNITED STATES) 270 (10): 5625-30. ISSN 0021-9258. PMID 7890683.

[pmid12015308-16] Guerrero-Esteo, Mercedes; Sanchez-Elsner Tilman, Letamendia Ainhoa, Bernabeu Carmelo (Aug. de 2002). «Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II». J. Biol. Chem. (United States) 277 (32): 29197-209. ISSN 0021-9258. PMID 12015308. doi:10.1074/jbc.M111991200.

[pmid9872992-17] Barbara, N P; Wrana J L, Letarte M (Jan. de 1999). «Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily». J. Biol. Chem. (UNITED STATES) 274 (2): 584-94. ISSN 0021-9258. PMID 9872992.

[pmid18591668-18] Wrighton, Katharine H; Lin Xia, Feng Xin-Hua (Jul. de 2008). «Critical regulation of TGFbeta signaling by Hsp90». Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (27): 9244-9. PMID 18591668. doi:10.1073/pnas.0800163105.

[pmid9856985-19] Datta, P K; Chytil A, Gorska A E, Moses H L (Dec. de 1998). «Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling». J. Biol. Chem. (UNITED STATES) 273 (52): 34671-4. ISSN 0021-9258. PMID 9856985.

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