STAT5A

Transductor de señales y activador transcripcional 5A
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1y1u
Identificadores
Símbolos	STAT5A (HGNC: 11366) MGF, STAT5
Identificadores; externos	OMIM: 601511 ; EBI: STAT5A; GeneCards: Gen STAT5A; UniProt: STAT5A;
Locus	Cr. 17 q21.2
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
6776
P42229	n/a
NP_003143	n/a
	v; t; e;
	[editar datos en Wikidata]

El transductor de señales y activador transcripcional 5A (STAT5A) es una proteína codificada en humanos por el gen stat5A.^[1]^[2]

Esta proteína pertenece a la familia de los factores de transcripción STAT. En respuesta a las citoquinas y a los factores de crecimiento, los miembros de la familia STAT son fosforilados por receptores asociados a quinasas, formando homo- o heterodímeros que se translocan al núcleo donde actúan como activadores transcripcionales. La proteína STAT5B es un intermediario de la transducción de señales iniciada por diferentes ligandos, tales como IL-2, IL-3, IL-7, GM-CSF, eritropoyetina, trombopoyetina y diversas hormonas de crecimiento. La activación de esta proteína en mielomas y linfomas asociados con la fusión TEL/JAK2 es independiente del estímulo celular a que se vea sometida, y ha demostrado ser esencial en el proceso de tumorogénesis. El ortólogo de este gen en ratón es capaz de inducir la expresión de BCL2L1/BCL-X(L), lo que sugiere una función anti-apoptótica de este gen.^[3]

Interacciones[editar]

La proteína STAT5A ha demostrado ser capaz de interaccionar con:

Véase también[editar]

STAT5

Referencias[editar]

↑ Hou J, Schindler U, Henzel WJ, Wong SC, McKnight SL (mayo de 1995). «Identification and purification of human Stat proteins activated in response to interleukin-2». Immunity 2 (4): 321-9. PMID 7719937.
↑ Lin JX, Mietz J, Modi WS, John S, Leonard WJ (Jul de 1996). «Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells». J Biol Chem 271 (18): 10738-44. PMID 8631883.
↑ «Entrez Gene: STAT5A signal transducer and activator of transcription 5A».
↑ ^a ^b Schulze, Waltraud X; Deng Lei, Mann Matthias (2005). «Phosphotyrosine interactome of the ErbB-receptor kinase family». Mol. Syst. Biol. (England) 1: 2005.0008. PMID 16729043. doi:10.1038/msb4100012.
↑ Olayioye, M A; Beuvink I, Horsch K, Daly J M, Hynes N E (Jun. de 1999). «ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases». J. Biol. Chem. (UNITED STATES) 274 (24): 17209-18. ISSN 0021-9258. PMID 10358079.
↑ Zhu, M; John S, Berg M, Leonard W J (Jan. de 1999). «Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling». Cell (UNITED STATES) 96 (1): 121-30. ISSN 0092-8674. PMID 9989503.
↑ Williams, Christopher C; Allison June G, Vidal Gregory A, Burow Matthew E, Beckman Barbara S, Marrero Luis, Jones Frank E (Nov. de 2004). «The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone». J. Cell Biol. (United States) 167 (3): 469-78. ISSN 0021-9525. PMID 15534001. doi:10.1083/jcb.200403155.
↑ Yu, C L; Jin Y J, Burakoff S J (Jan. de 2000). «Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation». J. Biol. Chem. (UNITED STATES) 275 (1): 599-604. ISSN 0021-9258. PMID 10617656.
↑ Chughtai, Naila; Schimchowitsch Sarah, Lebrun Jean-Jacques, Ali Suhad (Aug. de 2002). «Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells». J. Biol. Chem. (United States) 277 (34): 31107-14. ISSN 0021-9258. PMID 12060651. doi:10.1074/jbc.M200156200.
↑ Chin, H; Nakamura N, Kamiyama R, Miyasaka N, Ihle J N, Miura O (Dec. de 1996). «Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3». Blood (UNITED STATES) 88 (12): 4415-25. ISSN 0006-4971. PMID 8977232.
↑ Barahmand-Pour, F; Meinke A; Groner B; Decker T (mayo. de 1998). «Jak2-Stat5 interactions analyzed in yeast». J. Biol. Chem. (UNITED STATES) 273 (20): 12567-75. ISSN 0021-9258. PMID 9575217.
↑ ^a ^b Fujitani, Y; Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (Feb. de 1997). «An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT». Oncogene (ENGLAND) 14 (7): 751-61. ISSN 0950-9232. PMID 9047382. doi:10.1038/sj.onc.1200907.
↑ Ota, J; Kimura F; Sato K; Wakimoto N; Nakamura Y; Nagata N; Suzu S; Yamada M; Shimamura S; Motoyoshi K (Nov. de 1998). «Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin». Biochem. Biophys. Res. Commun. (UNITED STATES) 252 (3): 779-86. ISSN 0006-291X. PMID 9837784. doi:10.1006/bbrc.1998.9445.
↑ Pircher, T J; Petersen H, Gustafsson J A, Haldosén L A (Apr. de 1999). «Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a». Mol. Endocrinol. (UNITED STATES) 13 (4): 555-65. ISSN 0888-8809. PMID 10194762.
↑ Dinerstein-Cali, H; Ferrag F, Kayser C, Kelly P A, Postel-Vinay M (Aug. de 2000). «Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins». Mol. Cell. Endocrinol. (IRELAND) 166 (2): 89-99. ISSN 0303-7207. PMID 10996427.

Datos: Q18031751

[pmid7719937-1] Hou J, Schindler U, Henzel WJ, Wong SC, McKnight SL (mayo de 1995). «Identification and purification of human Stat proteins activated in response to interleukin-2». Immunity 2 (4): 321-9. PMID 7719937.

[pmid8631883-2] Lin JX, Mietz J, Modi WS, John S, Leonard WJ (Jul de 1996). «Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells». J Biol Chem 271 (18): 10738-44. PMID 8631883.

[3] «Entrez Gene: STAT5A signal transducer and activator of transcription 5A».

[pmid16729043-4] Schulze, Waltraud X; Deng Lei, Mann Matthias (2005). «Phosphotyrosine interactome of the ErbB-receptor kinase family». Mol. Syst. Biol. (England) 1: 2005.0008. PMID 16729043. doi:10.1038/msb4100012.

[pmid10358079-5] Olayioye, M A; Beuvink I, Horsch K, Daly J M, Hynes N E (Jun. de 1999). «ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases». J. Biol. Chem. (UNITED STATES) 274 (24): 17209-18. ISSN 0021-9258. PMID 10358079.

[pmid9989503-6] Zhu, M; John S, Berg M, Leonard W J (Jan. de 1999). «Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling». Cell (UNITED STATES) 96 (1): 121-30. ISSN 0092-8674. PMID 9989503.

[pmid15534001-7] Williams, Christopher C; Allison June G, Vidal Gregory A, Burow Matthew E, Beckman Barbara S, Marrero Luis, Jones Frank E (Nov. de 2004). «The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone». J. Cell Biol. (United States) 167 (3): 469-78. ISSN 0021-9525. PMID 15534001. doi:10.1083/jcb.200403155.

[pmid10617656-8] Yu, C L; Jin Y J, Burakoff S J (Jan. de 2000). «Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation». J. Biol. Chem. (UNITED STATES) 275 (1): 599-604. ISSN 0021-9258. PMID 10617656.

[pmid12060651-9] Chughtai, Naila; Schimchowitsch Sarah, Lebrun Jean-Jacques, Ali Suhad (Aug. de 2002). «Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells». J. Biol. Chem. (United States) 277 (34): 31107-14. ISSN 0021-9258. PMID 12060651. doi:10.1074/jbc.M200156200.

[pmid8977232-10] Chin, H; Nakamura N, Kamiyama R, Miyasaka N, Ihle J N, Miura O (Dec. de 1996). «Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3». Blood (UNITED STATES) 88 (12): 4415-25. ISSN 0006-4971. PMID 8977232.

[pmid9575217-11] Barahmand-Pour, F; Meinke A; Groner B; Decker T (mayo. de 1998). «Jak2-Stat5 interactions analyzed in yeast». J. Biol. Chem. (UNITED STATES) 273 (20): 12567-75. ISSN 0021-9258. PMID 9575217.

[pmid9047382-12] Fujitani, Y; Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (Feb. de 1997). «An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT». Oncogene (ENGLAND) 14 (7): 751-61. ISSN 0950-9232. PMID 9047382. doi:10.1038/sj.onc.1200907.

[pmid9837784-13] Ota, J; Kimura F; Sato K; Wakimoto N; Nakamura Y; Nagata N; Suzu S; Yamada M; Shimamura S; Motoyoshi K (Nov. de 1998). «Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin». Biochem. Biophys. Res. Commun. (UNITED STATES) 252 (3): 779-86. ISSN 0006-291X. PMID 9837784. doi:10.1006/bbrc.1998.9445.

[pmid10194762-14] Pircher, T J; Petersen H, Gustafsson J A, Haldosén L A (Apr. de 1999). «Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a». Mol. Endocrinol. (UNITED STATES) 13 (4): 555-65. ISSN 0888-8809. PMID 10194762.

[pmid10996427-15] Dinerstein-Cali, H; Ferrag F, Kayser C, Kelly P A, Postel-Vinay M (Aug. de 2000). «Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins». Mol. Cell. Endocrinol. (IRELAND) 166 (2): 89-99. ISSN 0303-7207. PMID 10996427.

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