MEF2C

Factor potenciador específico de miocito 2C
	; Estructura tridimensional de la proteína MEF2C.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1c7u
Identificadores
Símbolo	MEF2C (HGNC: 6996)
Identificadores; externos	OMIM: 600662 ; EBI: MEF2C; GeneCards: Gen MEF2C; UniProt: MEF2C;
Locus	Cr. 5 q14.3
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
4208
Q06413	n/a
NP_002388	n/a
	v; t; e;
	[editar datos en Wikidata]

El factor potenciador específico de miocito 2C (MEF2C, de sus siglas en inglés "Myocyte-specific enhancer factor 2C") es una proteína codificada en humanos por el gen mef2C. MEF2C es un factor de transcripción de la familia Mef2.^[1]^[2] Esta proteína es necesaria para el correcto desarrollo embrionario: ratones knockout que no poseen una copia funcional del gen mef2C mueren antes de nacer y tienen anomalías en el corazón y en el sistema vascular.^[3]

Interacciones

El factor potenciador específico de miocito 2A ha demostrado ser capaz de interaccionar con:

Véase también

MEF2

Referencias

↑ Molkentin JD, Black BL, Martin JF, Olson EN (1996). «Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.». Mol Cell Biol. 16 (6): 2627-36. PMID 8649370.
↑ «Entrez Gene: MEF2C myocyte enhancer factor 2C».
↑ Bi W, Drake CJ, Schwarz JJ (1999). «The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF». Developmental Biology 211 (2): 255-67. PMID 10395786. doi:10.1006/dbio.1999.9307.
↑ Yang, C C; Ornatsky O I, McDermott J C, Cruz T F, Prody C A (Oct. de 1998). «Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1». Nucleic Acids Res. (ENGLAND) 26 (20): 4771-7. ISSN 0305-1048. PMID 9753748.
↑ Sartorelli, V; Huang J; Hamamori Y; Kedes L (Feb. de 1997). «Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C». Mol. Cell. Biol. (UNITED STATES) 17 (2): 1010-26. ISSN 0270-7306. PMID 9001254.
↑ Krainc, D; Bai G, Okamoto S, Carles M, Kusiak J W, Brent R N, Lipton S A (Oct. de 1998). «Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1». J. Biol. Chem. (UNITED STATES) 273 (40): 26218-24. ISSN 0021-9258. PMID 9748305.
↑ Maeda, Tomoji; Gupta Mahesh P, Stewart Alexandre F R (Jun. de 2002). «TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters». Biochem. Biophys. Res. Commun. (United States) 294 (4): 791-7. ISSN 0006-291X. PMID 12061776. doi:10.1016/S0006-291X(02)00556-9.
↑ Hosking, B M; Wang S C, Chen S L, Penning S, Koopman P, Muscat G E (Sep. de 2001). «SOX18 directly interacts with MEF2C in endothelial cells». Biochem. Biophys. Res. Commun. (United States) 287 (2): 493-500. ISSN 0006-291X. PMID 11554755. doi:10.1006/bbrc.2001.5589.
↑ Wang, A H; Bertos N R, Vezmar M, Pelletier N, Crosato M, Heng H H, Th'ng J, Han J, Yang X J (Nov. de 1999). «HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor». Mol. Cell. Biol. (UNITED STATES) 19 (11): 7816-27. ISSN 0270-7306. PMID 10523670.
↑ Wang, A H; Yang X J (Sep. de 2001). «Histone deacetylase 4 possesses intrinsic nuclear import and export signals». Mol. Cell. Biol. (United States) 21 (17): 5992-6005. ISSN 0270-7306. PMID 11486037.

Enlaces externos

MeSH: MEF2C+protein,+human (en inglés)

Datos: Q18029008

[1] Molkentin JD, Black BL, Martin JF, Olson EN (1996). «Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.». Mol Cell Biol. 16 (6): 2627-36. PMID 8649370.

[2] «Entrez Gene: MEF2C myocyte enhancer factor 2C».

[3] Bi W, Drake CJ, Schwarz JJ (1999). «The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF». Developmental Biology 211 (2): 255-67. PMID 10395786. doi:10.1006/dbio.1999.9307.

[pmid9753748-4] Yang, C C; Ornatsky O I, McDermott J C, Cruz T F, Prody C A (Oct. de 1998). «Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1». Nucleic Acids Res. (ENGLAND) 26 (20): 4771-7. ISSN 0305-1048. PMID 9753748.

[pmid9001254-5] Sartorelli, V; Huang J; Hamamori Y; Kedes L (Feb. de 1997). «Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C». Mol. Cell. Biol. (UNITED STATES) 17 (2): 1010-26. ISSN 0270-7306. PMID 9001254.

[pmid9748305-6] Krainc, D; Bai G, Okamoto S, Carles M, Kusiak J W, Brent R N, Lipton S A (Oct. de 1998). «Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1». J. Biol. Chem. (UNITED STATES) 273 (40): 26218-24. ISSN 0021-9258. PMID 9748305.

[pmid12061776-7] Maeda, Tomoji; Gupta Mahesh P, Stewart Alexandre F R (Jun. de 2002). «TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters». Biochem. Biophys. Res. Commun. (United States) 294 (4): 791-7. ISSN 0006-291X. PMID 12061776. doi:10.1016/S0006-291X(02)00556-9.

[pmid11554755-8] Hosking, B M; Wang S C, Chen S L, Penning S, Koopman P, Muscat G E (Sep. de 2001). «SOX18 directly interacts with MEF2C in endothelial cells». Biochem. Biophys. Res. Commun. (United States) 287 (2): 493-500. ISSN 0006-291X. PMID 11554755. doi:10.1006/bbrc.2001.5589.

[pmid10523670-9] Wang, A H; Bertos N R, Vezmar M, Pelletier N, Crosato M, Heng H H, Th'ng J, Han J, Yang X J (Nov. de 1999). «HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor». Mol. Cell. Biol. (UNITED STATES) 19 (11): 7816-27. ISSN 0270-7306. PMID 10523670.

[pmid11486037-10] Wang, A H; Yang X J (Sep. de 2001). «Histone deacetylase 4 possesses intrinsic nuclear import and export signals». Mol. Cell. Biol. (United States) 21 (17): 5992-6005. ISSN 0270-7306. PMID 11486037.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]