Usuario:Joseaperez/OR

	Casos	Control	Total
Expuestos	a	b	a+b
No expuestos	c	d	c+d
Total	a+c	b+d	N

Name	Source ​	Target receptors​​	Target cells​	Function​
IL-1	macrophages, B cells, monocytes,​ dendritic cells ​	CD121a/IL1R1, CD121b/IL1R2	T helper cells	co-stimulation ​
			B cells	maturation & proliferation ​
			NK cells	activation​
			macrophages, endothelium, other	inflammation,​ small amounts induce acute phase reaction, large amounts induce fever
IL-2	Th1-cells	CD25/IL2RA, CD122/IL2RB, CD132/IL2RG	activated​ T cells and B cells, NK cells, macrophages, oligodendrocytes	stimulates growth and differentiation of T cell response. Can be used in immunotherapy to treat cancer or suppressed for transplant patients. Has also been used in clinical trials (ESPIRIT. Stalwart) to raise CD4 counts in HIV positive patients.
IL-3	activated T helper cells,​ mast cells, NK cells, endothelium, eosinophils	CD123/IL3RA, CD131/IL3RB	hematopoietic stem cells	differentiation and proliferation of myeloid progenitor cells ​ to e.g. erythrocytes, granulocytes
			mast cells	growth and histamine release​
IL-4	Th2 cells, just activated naive CD4+ cell, memory CD4+ cells, mast cells, macrophages	CD124/IL4R, CD132/IL2RG	activated B cells	proliferation and differentiation, IgG1 and IgE synthesis.​ Important role in allergic response (IgE)
			T cells	proliferation​
			endothelium	increase expression of vascular cell adhesion molecule (VCAM-1) promoting adhesion of lymphocytes.​
IL-5	Th2 cells, mast cells, eosinophils	CD125/IL5RA, CD131/IL3RB	eosinophils	production
			B cells	differentiation, IgA production
IL-6	macrophages, Th2 cells, B cells, astrocytes, endothelium	CD126/IL6RA, CD130/IR6RB	activated B cells	differentiation into plasma cells
			plasma cells	antibody secretion
			hematopoietic stem cells	differentiation
			T cells, others	induces acute phase reaction, hematopoiesis, differentiation, inflammation
IL-7	Bone marrow stromal cells and thymus stromal cells	CD127/IL7RA, CD132/IL2RG	pre/pro-B cell, pre/pro-T cell, NK cells	differentiation and proliferation of lymphoid progenitor cells, involved in B, T, and NK cell survival, development, and homeostasis, ↑proinflammatory cytokines
IL-8 or CXCL8	macrophages, lymphocytes, epithelial cells, endothelial cells	CXCR1/IL8RA, CXCR2/IL8RB/CD128	neutrophils, basophils, lymphocytes	Neutrophil chemotaxis
IL-9	Th2 cells, specifically by CD4+ helper cells	CD129/IL9R	T cells, B cells	Potentiates IgM, IgG, IgE, stimulates mast cells
IL-10	monocytes, Th2 cells, CD8+ T cells, mast cells, macrophages, B cell subset	CD210/IL10RA, CDW210B/IL10RB	macrophages	cytokine production​
			B cells	activation ​
			mast cells
			Th1 cells	inhibits Th1 cytokine production (IFN-γ, TNF-β, IL-2)
			Th2 cells	Stimulation
IL-11	bone marrow stroma	IL11RA	bone marrow stroma	acute phase protein production, osteoclast formation
IL-12	dendritic cells, B cells, T cells, macrophages	CD212/IL12RB1, IR12RB2	activated ​ T cells,	differentiation into Cytotoxic T cells with IL-2,​ ↑ IFN-γ, TNF-α, ↓ IL-10
			NK cells	↑ IFN-γ, TNF-α
IL-13	activated Th2 cells, mast cells, NK cells	IL13R	TH2-cells, B cells, macrophages	Stimulates growth and differentiation of B cells (IgE), inhibits TH1-cells and the production of macrophage inflammatory cytokines (e.g. IL-1, IL-6), ↓ IL-8, IL-10, IL-12
IL-14	T cells and certain malignant B cells		activated B cells	controls the growth and proliferation of B cells, inhibits Ig secretion
IL-15	mononuclear phagocytes (and some other cells), especially macrophages following infection by virus(es)	IL15RA	T cells, activated B cells	Induces production of Natural killer cells
IL-16	lymphocytes, epithelial cells, eosinophils, CD8+ T cells	CD4	CD4+ T cells (Th-cells)	CD4+ chemoattractant
IL-17	T helper 17 cells (Th17)	CDw217/IL17RA, IL17RB	epithelium, endothelium, other	osteoclastogenesis, angiogenesis, ↑ inflammatory cytokines
IL-18	macrophages m,v,v,lkj,vn,	CDw218a/IL18R1	Th1 cells, NK cells	Induces production of IFNγ, ↑ NK cell activity
IL-19	-	IL20R		-
IL-20	Activated keratinocytes and monocytes	IL20R		regulates proliferation and differentiation of keratinocytes
IL-21	activated T helper cells, NKT cells	IL21R	All lymphocytes, dendritic cells	costimulates activation and proliferation of CD8+ T cells, augment NK cytotoxicity, augments CD40-driven B cell proliferation, differentiation and isotype switching, promotes differentiation of Th17 cells
IL-22	T helper 17 cells (Th17)	IL22R		Production of defensins from epithelial cells.​ Activates STAT1 and STAT3 and increases production of acute phase proteins such as serum amyloid A, Alpha 1-antichymotrypsin and haptoglobin in hepatoma cell lines
IL-23	macrophages, dendritic cells	IL23R		Maintenance of IL-17 producing cells,​ increases angiogenesis but reduces CD8 T-cell infiltration
IL-24	melanocytes, keratinocytes, monocytes, T cells	IL20R		Plays important roles in tumor suppression, wound healing and psoriasis by influencing cell survival, inflammatory cytokine expression.
IL-25	T Cells, mast cells, eosinophils, macrophages, mucosal epithelial cells	LY6E		Induces the production IL-4, IL-5 and IL-13, which stimulate eosinophil expansion
IL-26	T cells, monocytes	IL20R1		Enhances secretion of IL-10 and IL-8 and cell surface expression of CD54 on epithelial cells
IL-27	macrophages, dendritic cells	IL27RA		Regulates the activity of B lymphocyte and T lymphocytes
IL-28	-	IL28R		Plays a role in immune defense against viruses
IL-29	-			Plays a role in host defenses against microbes
IL-30	-			Forms one chain of IL-27
IL-31	Th2 cells	IL31RA		May play a role in inflammation of the skin
IL-32	-			Induces monocytes and macrophages to secrete TNF-α, IL-8 and CXCL2
IL-33	epithelial cells			Induces helper T cells to produce type 2 cytokine
IL-35	regulatory T cells			Suppression of T helper cell activation
IL-36	-			Regulates DC and T cell responses