Insulisina
La insulisina (EC 3.4.24.56 3.4.24.56) (También llamada insulinasa, enzima degradante de insulina, insulina proteasa, insulina proteinasa, insulina-glucagón proteasa, metaloinsulinasa, IDE) es una enzima.[1][2][3][4][5] Esta enzima cataliza la reacción de degradación de insulina, glucagón y otros polipéptidos.
Esta enzima citosólica está presente en mamíferos y en muchos artrópodos como la mosca Drosophila melanogaster.
Referencias
[editar]- ↑ «Insulin degradation: mechanisms, products, and significance». Endocrine Reviews 9 (3): 319-45. August 1988. PMID 3061785. doi:10.1210/edrv-9-3-319.
- ↑ «Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes». Molecular Endocrinology 4 (8): 1125-35. August 1990. PMID 2293021. doi:10.1210/mend-4-8-1125.
- ↑ «Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin». The Journal of Biological Chemistry 265 (5): 2984-7. February 1990. PMID 1689296.
- ↑ «Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme». Molecular Endocrinology 4 (10): 1580-91. October 1990. PMID 2126597. doi:10.1210/mend-4-10-1580.
- ↑ «Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III». The Journal of Biological Chemistry 267 (4): 2414-20. February 1992. PMID 1733942.
