La subunidad beta hormona estimulante de la tiroides, también conocida como TSHB (del inglés: Thyroid stimulating hormone, beta) es una proteína que en humanos es codificada por el genTSHB.[1][2]
La TSH es una glicoproteína heterodímero ligada no covalentemente y es parte de la familia de hormonas pituitarias conteniendo una subunidad alfa común (TSHA) y una subunidad beta única (esta proteína) que confiere especificidad.[3]
↑Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K (diciembre de 1988). «The structure of the human thyrotropin beta-subunit gene». Gene73 (2): 489-97. PMID3243440. doi:10.1016/0378-1119(88)90513-6.
Bonomi M, Proverbio MC, Weber G, et al. (2001). «Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene.». J. Clin. Endocrinol. Metab.86 (4): 1600-4. PMID11297590. doi:10.1210/jc.86.4.1600.
Vuissoz JM, Deladoëy J, Buyukgebiz A, et al. (2001). «New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism.». J. Clin. Endocrinol. Metab.86 (9): 4468-71. PMID11549695. doi:10.1210/jc.86.9.4468.
Karges B, LeHeup B, Schoenle E, et al. (2004). «Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe.». Horm. Res.62 (3): 149-55. PMID15297803. doi:10.1159/000080071.
Kabadi UM, Premachandra BN (2007). «Serum thyrotropin in Graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function?». Endocr Pract13 (6): 615-9. PMID17954417.
Miyai S, Yoshimura S, Iwasaki Y, et al. (2005). «Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line.». Cell Tissue Res.322 (2): 269-77. PMID16133148. doi:10.1007/s00441-005-0033-z.
Pohlenz J, Dumitrescu A, Aumann U, et al. (2002). «Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene.». J. Clin. Endocrinol. Metab.87 (1): 336-9. PMID11788671. doi:10.1210/jc.87.1.336.
Miyoshi I, Kasai N, Hayashizaki Y (1994). «[Structure and regulation of human thyroid-stimulating hormone (TSH) gene]». Nippon Rinsho52 (4): 940-7. PMID8196184.
Borck G, Topaloglu AK, Korsch E, et al. (2004). «Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect.». J. Clin. Endocrinol. Metab.89 (8): 4136-41. PMID15292359. doi:10.1210/jc.2004-0494.
Comings DE, Gade-Andavolu R, Gonzalez N, et al. (2000). «A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.». Clin. Genet.58 (5): 375-85. PMID11140838. doi:10.1034/j.1399-0004.2000.580508.x.
Brumm H, Pfeufer A, Biebermann H, et al. (2002). «Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect.». J. Clin. Endocrinol. Metab.87 (10): 4811-6. PMID12364478. doi:10.1210/jc.2002-020297.
Benhadi N, Wiersinga WM, Reitsma JB, et al. (2009). «Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death.». Eur. J. Endocrinol.160 (6): 985-91. PMID19273570. doi:10.1530/EJE-08-0953.