Alfa 2-antiplasmina

Imagen simplificada del proceso de fibrinolisis. Las flechas azules indican activación, mientras que las flechas rojas indican inhibición.

La alfa 2-antiplasmina (α₂-antiplasmina o inhibidor de la plasmina) es una glicoproteína de cadena simple sintetizada en el hígado y que funciona como serina proteasa inhibitora, una enzima que inactiva a la plasmina. Su acción enzimática es vital en el proceso de fibrinolisis y en la degradación de otras proteínas. El gen que codifica a la α₂-antiplasmina es conocida como HGNC SERPINF2 .^[1]

En casos muy infrecuentes, aparece una deficiencia de α₂-antiplasmina. La inhibición anormal de la α₂-antiplasmina conlleva a una tendencia al sangrado.

La α₂-antiplasmina interactúa con la plasmina^[2]^[3] y la proteína elastasa de neutrófilos.^[4]^[3]

Referencias

↑ «Entrez Gene: SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2».
↑ Wiman, B; Collen D (Sep. de 1979). «On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin». J. Biol. Chem. (UNITED STATES) 254 (18): 9291-7. ISSN 0021-9258. PMID 158022.
↑ ^a ^b Shieh, B H; Travis J (May. de 1987). «The reactive site of human alpha 2-antiplasmin». J. Biol. Chem. (UNITED STATES) 262 (13): 6055-9. ISSN 0021-9258. PMID 2437112.
↑ Brower, M S; Harpel P C (Aug. de 1982). «Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase». J. Biol. Chem. (UNITED STATES) 257 (16): 9849-54. ISSN 0021-9258. PMID 6980881.

Enlaces externos

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MeSH: alpha-2+Antiplasmin (en inglés)
MeSH: SERPINF2+protein,+human (en inglés)

[entrez-1] «Entrez Gene: SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2».

[pmid158022-2] Wiman, B; Collen D (Sep. de 1979). «On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin». J. Biol. Chem. (UNITED STATES) 254 (18): 9291-7. ISSN 0021-9258. PMID 158022.

[pmid2437112-3] Shieh, B H; Travis J (May. de 1987). «The reactive site of human alpha 2-antiplasmin». J. Biol. Chem. (UNITED STATES) 262 (13): 6055-9. ISSN 0021-9258. PMID 2437112.

[pmid6980881-4] Brower, M S; Harpel P C (Aug. de 1982). «Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase». J. Biol. Chem. (UNITED STATES) 257 (16): 9849-54. ISSN 0021-9258. PMID 6980881.

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