Usuario:Rgescudero/Taller
| Rgescudero/Taller | ||
|---|---|---|
 | ||
| Información personal | ||
| Nombre nativo | Ramón García Escudero | |
| Nacimiento |
16 de septiembre de 1968 Albacete | |
| Nacionalidad | España | |
| Educación | ||
| Educado en | Universidad Autónoma de Madrid | |
Ramon Garcia-Escudero (born September 1968 in Albacete) is a Spanish molecular biologist whose main scientific contributions are in the fields of molecular virology and molecular oncology. He worked as a PhD student in the Eladio Viñuela's laboratory and the Centro de Biología Molecular Severo Ochoa in Madrid, Spain. He developed an inducible system for expression of African swine fever virus (ASFV) genes[1]. Such inducible system has been (and still is) key to discover the functions of many viral genes, mainly during ASFV morphogenesis and maturation.
Since 2001, he has been working with oncogenic subtypes of human papillomavirus (HPV) at the Cancer Research UK (CRUK, London, UK), and thereafter in different human epithelial cancers at Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) (in Madrid, Spain) and at the Institute of Oncology Research (IOR) (in Bellinzona, Switzerland).
During this time, he has published more than 70 scientific articles in international journals, and participated in 18 granted projects, 4 of them as principal investigator form national and international public/private organizations.
His main research interests in cancer include:
i) finding new and efficient antitumor therapies.
ii) developing tools for early diagnosis.
In order to achieve such goals, he’s being combining modern technologies of cancer genomics and bioinformatics with generation of new disease models, including genetically modified mouse models. Actual main interest is translational research in head and neck cancer of Fanconi anemia patients.
Some of his most important publications include:
- “Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway” (2018)[2].
- “A humanized mouse model of HPV-associated pathology driven by E7 expression” (2012)[3].
- “Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy” (2010)[4]
- “Inducible gene expression from African swine fever virus recombinants: analysis of the major capsid protein p72” (1998)[5].
He has also significantly contributed to others people’s research, published in outstanding journal such as Nature, Nature Genetics or Nature Communications:
- “Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer” (2018)[6]
- “A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers. ” (2017)[7]
- “Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer" (2014)[8]
References[editar]
- ↑ García-Escudero, R; Andrés, G; Almazán, F; Viñuela, E (de abril de 1998). «Inducible gene expression from African swine fever virus recombinants: analysis of the major capsid protein p72.». Journal of virology 72 (4): 3185-95. PMID 9580160.
- ↑ García-Escudero, R; Segrelles, C; Dueñas, M; Pombo, M; Ballestín, C; Alonso-Riaño, M; Nenclares, P; Álvarez-Rodríguez, R; Sánchez-Aniceto, G; Ruíz-Alonso, A; López-Cedrún, JL; Paramio, JM; Lorz, C (de abril de 2018). «Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway.». Oral oncology 79: 55-63. PMID 29598951.
- ↑ Buitrago-Pérez, Á; Hachimi, M; Dueñas, M; Lloveras, B; Santos, A; Holguín, A; Duarte, B; Santiago, JL; Akgül, B; Rodríguez-Peralto, JL; Storey, A; Ribas, C; Larcher, F; del Rio, M; Paramio, JM; García-Escudero, R (de de 2012). «A humanized mouse model of HPV-associated pathology driven by E7 expression.». PloS one 7 (7): e41743. PMID 22911850.
- ↑ García-Escudero, R; Martínez-Cruz, AB; Santos, M; Lorz, C; Segrelles, C; Garaulet, G; Saiz-Ladera, C; Costa, C; Buitrago-Pérez, A; Dueñas, M; Paramio, JM (14 de julio de 2010). «Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy.». Molecular cancer 9: 193. PMID 20630075.
- ↑ García-Escudero, R; Andrés, G; Almazán, F; Viñuela, E (de abril de 1998). «Inducible gene expression from African swine fever virus recombinants: analysis of the major capsid protein p72.». Journal of virology 72 (4): 3185-95. PMID 9580160.
- ↑ Chen, J; Guccini, I; Di Mitri, D; Brina, D; Revandkar, A; Sarti, M; Pasquini, E; Alajati, A; Pinton, S; Losa, M; Civenni, G; Catapano, CV; Sgrignani, J; Cavalli, A; D'Antuono, R; Asara, JM; Morandi, A; Chiarugi, P; Crotti, S; Agostini, M; Montopoli, M; Masgras, I; Rasola, A; Garcia-Escudero, R; Delaleu, N; Rinaldi, A; Bertoni, F; Bono, J; Carracedo, A; Alimonti, A (de febrero de 2018). «Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.». Nature genetics 50 (2): 219-228. PMID 29335542.
- ↑ Pisignano, G; Napoli, S; Magistri, M; Mapelli, SN; Pastori, C; Di Marco, S; Civenni, G; Albino, D; Enriquez, C; Allegrini, S; Mitra, A; D'Ambrosio, G; Mello-Grand, M; Chiorino, G; Garcia-Escudero, R; Varani, G; Carbone, GM; Catapano, CV (30 de mayo de 2017). «A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers.». Nature communications 8: 15622. PMID 28555645.
- ↑ Di Mitri, D; Toso, A; Chen, JJ; Sarti, M; Pinton, S; Jost, TR; D'Antuono, R; Montani, E; Garcia-Escudero, R; Guccini, I; Da Silva-Alvarez, S; Collado, M; Eisenberger, M; Zhang, Z; Catapano, C; Grassi, F; Alimonti, A (6 de noviembre de 2014). «Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer.». Nature 515 (7525): 134-7. PMID 25156255.