BCL6

Proteína 6 del linfoma de células B
	; Estructura tridimensional de la proteína BCL6.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1r28
Identificadores
Símbolos	BCL6 (HGNC: 1001) BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Identificadores; externos	OMIM: 109565 ; EBI: BCL6; GeneCards: Gen BCL6; UniProt: BCL6;
Locus	Cr. 3 q27.3
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
604
P41182	n/a
NP_001697	n/a
	v; t; e;
	[editar datos en Wikidata]

La proteína 6 del linfoma de células B (BCL6) es una proteína codificada en humanos por el gen bcl6.^[1]

La proteína BCL6 es un factor de transcripción con un dominio de dedos de zinc y un dominio POZ en el dominio N-terminal. Esta proteína actúa como un represor de la transcripción específico de secuencia y se ha observado que regula la transcripción de los genes implicados en la respuesta de IL-4 dependiente de STAT en células B. BCL6 puede interaccionar con una variedad de proteínas con dominios POZ, actuando como un correpresor de la transcripción. El gen bcl6 se encuentra frecuentemente traslocado e hipermutado en patologías como el Linfoma difuso de células B grandes. Se han descrito dos variantes transcripcionales de este gen, que codifican la misma proteína.^[1]

Interacciones

La proteína BCL6 ha demostrado ser capaz de interaccionar con:

HDAC5^[2]
HDAC1^[3]^[4]
HDAC7A^[2]
ZBTB7A^[5]
Dedo de zinc y dominio BTB de la proteína 16^[6]
HDAC4^[2]
NCOR2^[4]^[7]^[8]
BCOR^[7]
c-Jun^[9]
IRF4^[10]

Véase también

Referencias

↑ ^a ^b «Entrez Gene: BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51)».
↑ ^a ^b ^c Lemercier, Claudie; Brocard Marie-Paule, Puvion-Dutilleul Francine, Kao Hung-Ying, Albagli Olivier, Khochbin Saadi (Jun. de 2002). «Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor». J. Biol. Chem. (United States) 277 (24): 22045-52. ISSN 0021-9258. PMID 11929873. doi:10.1074/jbc.M201736200.
↑ David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A (mayo. de 1998). «Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein». Oncogene (ENGLAND) 16 (19): 2549-56. ISSN 0950-9232. PMID 9627120. doi:10.1038/sj.onc.1202043.
↑ ^a ^b Deltour, S; Guerardel C; Leprince D (Dec. de 1999). «Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (26): 14831-6. ISSN 0027-8424. PMID 10611298.
↑ Davies, J M; Hawe N, Kabarowski J, Huang Q H, Zhu J, Brand N J, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (Jan. de 1999). «Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene». Oncogene (ENGLAND) 18 (2): 365-75. ISSN 0950-9232. PMID 9927193. doi:10.1038/sj.onc.1202332.
↑ Dhordain, P; Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The H D, Zelent A, Koken M H (Dec. de 2000). «Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF». Oncogene (England) 19 (54): 6240-50. ISSN 0950-9232. PMID 11175338. doi:10.1038/sj.onc.1203976.
↑ ^a ^b Huynh, K D; Fischle W, Verdin E, Bardwell V J (Jul. de 2000). «BCoR, a novel corepressor involved in BCL-6 repression». Genes Dev. (UNITED STATES) 14 (14): 1810-23. ISSN 0890-9369. PMID 10898795.
↑ Wong, C W; Privalsky M L (Oct. de 1998). «Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6». J. Biol. Chem. (UNITED STATES) 273 (42): 27695-702. ISSN 0021-9258. PMID 9765306.
↑ Vasanwala, Farha H; Kusam Saritha, Toney Lisa M, Dent Alexander L (Aug. de 2002). «Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene». J. Immunol. (United States) 169 (4): 1922-9. ISSN 0022-1767. PMID 12165517.
↑ Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. de 1999). «Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4». J. Exp. Med. (UNITED STATES) 190 (12): 1837-48. ISSN 0022-1007. PMID 10601358.

Enlaces externos

MeSH: BCL6+protein,+human (en inglés)

Datos: Q17847411

[ncbi.nlm.nih.gov-1] «Entrez Gene: BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51)».

[pmid11929873-2] Lemercier, Claudie; Brocard Marie-Paule, Puvion-Dutilleul Francine, Kao Hung-Ying, Albagli Olivier, Khochbin Saadi (Jun. de 2002). «Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor». J. Biol. Chem. (United States) 277 (24): 22045-52. ISSN 0021-9258. PMID 11929873. doi:10.1074/jbc.M201736200.

[pmid9627120-3] David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A (mayo. de 1998). «Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein». Oncogene (ENGLAND) 16 (19): 2549-56. ISSN 0950-9232. PMID 9627120. doi:10.1038/sj.onc.1202043.

[pmid10611298-4] Deltour, S; Guerardel C; Leprince D (Dec. de 1999). «Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (26): 14831-6. ISSN 0027-8424. PMID 10611298.

[pmid9927193-5] Davies, J M; Hawe N, Kabarowski J, Huang Q H, Zhu J, Brand N J, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (Jan. de 1999). «Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene». Oncogene (ENGLAND) 18 (2): 365-75. ISSN 0950-9232. PMID 9927193. doi:10.1038/sj.onc.1202332.

[pmid11175338-6] Dhordain, P; Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The H D, Zelent A, Koken M H (Dec. de 2000). «Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF». Oncogene (England) 19 (54): 6240-50. ISSN 0950-9232. PMID 11175338. doi:10.1038/sj.onc.1203976.

[pmid10898795-7] Huynh, K D; Fischle W, Verdin E, Bardwell V J (Jul. de 2000). «BCoR, a novel corepressor involved in BCL-6 repression». Genes Dev. (UNITED STATES) 14 (14): 1810-23. ISSN 0890-9369. PMID 10898795.

[pmid9765306-8] Wong, C W; Privalsky M L (Oct. de 1998). «Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6». J. Biol. Chem. (UNITED STATES) 273 (42): 27695-702. ISSN 0021-9258. PMID 9765306.

[pmid12165517-9] Vasanwala, Farha H; Kusam Saritha, Toney Lisa M, Dent Alexander L (Aug. de 2002). «Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene». J. Immunol. (United States) 169 (4): 1922-9. ISSN 0022-1767. PMID 12165517.

[pmid10601358-10] Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. de 1999). «Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4». J. Exp. Med. (UNITED STATES) 190 (12): 1837-48. ISSN 0022-1007. PMID 10601358.

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