AMPD2
La AMP desaminasa 2 es una enzima que en humanos está codificada por el gen AMPD2.[1][2]
Los niveles altos de expresión de AMPD2 se correlacionan con un mal resultado del paciente y un fenotipo tumoral proliferativo en el sarcoma pleomórfico indiferenciado (UPS).[3]
Referencias
[editar]- ↑ Mahnke-Zizelman DK, Sabina RL (Nov 1992). «Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons». J Biol Chem 267 (29): 20866-77. PMID 1400401. doi:10.1016/S0021-9258(19)36768-7.
- ↑ «Entrez Gene: AMPD2 adenosine monophosphate deaminase 2 (isoform L)».
- ↑ Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, Stein S, Hölting TL, Cidrea-Aranaz F, Romero-Pérez L, Dallmayer M, Baldauf MC, Marchetto A, Sannino G, Knott MM, Wehweck F, Ohmura S, Li J, Hakozaki M, Kirchner T, Dandekar T, Butt E, Grünewald TG (September 2018). «Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma». International Journal of Cancer 144 (4): 859-867. PMID 30267407. doi:10.1002/ijc.31903.
Otras lecturas
[editar]- Bausch-Jurken MT, Mahnke-Zizelman DK, Morisaki T, Sabina RL (1992). «Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA.». J. Biol. Chem. 267 (31): 22407-13. PMID 1429593. doi:10.1016/S0021-9258(18)41686-9.
- Van den Bergh F, Sabina RL (1996). «Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L». Biochem. J. 312 (Pt 2): 401-10. PMC 1136276. PMID 8526848. doi:10.1042/bj3120401.
- Mahnke-Zizelman DK, van den Bergh F, Bausch-Jurken MT (1996). «Cloning, sequence and characterization of the human AMPD2 gene: evidence for transcriptional regulation by two closely spaced promoters». Biochim. Biophys. Acta 1308 (2): 122-32. PMID 8764830. doi:10.1016/0167-4781(96)00089-9.
- Haas AL, Sabina RL (2003). «N-terminal extensions of the human AMPD2 polypeptide influence ATP regulation of isoform L». Biochem. Biophys. Res. Commun. 305 (2): 421-7. PMID 12745092. doi:10.1016/S0006-291X(03)00787-3.
- Beausoleil SA, Villén J, Gerber SA (2006). «A probability-based approach for high-throughput protein phosphorylation analysis and site localization». Nat. Biotechnol. 24 (10): 1285-92. PMID 16964243. S2CID 14294292. doi:10.1038/nbt1240.
- Olsen JV, Blagoev B, Gnad F (2006). «Global, in vivo, and site-specific phosphorylation dynamics in signaling networks». Cell 127 (3): 635-48. PMID 17081983. S2CID 7827573. doi:10.1016/j.cell.2006.09.026.
Datos: Q17825468