English: Schematic overview of examples of the endurance (left) and resistance (right) exercise-induced muscle secretome and its auto-, para-, and endocrine actions involved in training adaptation. See text for details. Abbreviations: AMPK, AMP-dependent protein kinase; Apelin, APJ Endogenous Ligand; BAIBA, β-aminoisobutyric acid; BDNF, Brain-derived neurotrophic factor; BNP, B-type or brain natriuretic peptide; EC, endothelial cell; ECM, Extracellular matrix; GDF3, macrophage-derived growth differentiation factor 3; GDNF, glial cell line-derived neurotrophic factor, IGF-1, Insulin-like growth factor-1; ILC2, innate lymphoid cells type 2; IL-6, Interleukin-6; IL-8, Interleukin-8; IL-13, Interleukin-13; LIF, Leukemia inhibitory factor; MOTS-c, mitochondrial ORF of the 12S ribosomal RNA type-c; MMP2, Matrix metalloproteinase-2; mTORC1, mammalian target of rapamycin complex 1; NMJ, Neuromuscular junction; PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1α; SPARC, Secreted protein acidic and rich in cysteine; SPP-1, secreted phosphoprotein 1; TF, transcription factor; VEGF, Vascular endothelial growth factor; YAP1, Yes-associated protein 1.