Air date: Wednesday, September 23, 2020, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local Views: Total views: 706 (189 Live, 517 On-demand) Category: Immunology Runtime: 01:12:21 Description: IIG Seminar

Dr. Zuniga’s laboratory discovered that, in response to a viral infection, systemic type I interferons (IFN-I) are initially elevated but are subsequently and rapidly silenced despite continuous pathogen replication. They showed that there is an IFN-I refractory (or exhaustion) phase, during which the infected host fails to elevate IFN-I upon secondary unrelated infections, explaining delayed viral control and enhanced susceptibility to opportunistic infections. Dr. Zuniga will present their recent work on the mechanisms underlying the initial IFN-I elevation and its subsequent, rapid, suppression after viral infection.

For more information go to https://www.niaid.nih.gov/research/immunology-interest-group NLM Title: Type I interferon induction and exhaustion upon viral infection / Elina Zuniga. Author: Zuniga, Elina. National Institutes of Health (U.S.), Publisher: Abstract: (CIT): Dr. Zuniga's laboratory discovered that, in response to a viral infection, systemic type I interferons (IFN-I) are initially elevated but are subsequently and rapidly silenced despite continuous pathogen replication. They showed that there is an IFN-I refractory (or exhaustion) phase, during which the infected host fails to elevate IFN-I upon secondary unrelated infections, explaining delayed viral control and enhanced susceptibility to opportunistic infections. Dr. Zuniga will present their recent work on the mechanisms underlying the initial IFN-I elevation and its subsequent, rapid, suppression after viral infection. Subjects: Interferon Type I--immunology Virus Diseases--immunology Virus Diseases--virology Publication Types: Lecture Webcast

NLM Classification: WC 500 NLM ID: 101772209 CIT Live ID: 38716