Receptor de estrógeno alfa

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Receptor de estrógeno alfa

Estructura tridimensional del receptor de estrógeno alfa.
Estructuras disponibles
PDB Búsqueda en Human Uniprot: PDBeRCSB
Identificadores
Símbolos ESR1 (HUGO: 3467); ER; DKFZp686N23123; ESR; ESRA; Era; NR3A1
Identificadores externos OMIM133430 GeneCardsGen ESR1
Locus Cr. 6 q24-q27
Ortología
Especies Humano Ratón
Entrez 2099 n/a
UniProt P03372 n/a
RefSeq (mRNA) NP_000116 n/a

El receptor de estrógeno alfa, también denominado ER-alfa ó NR3A1 (de sus siglas en inglés "Nuclear receptor subfamily 3, group A, member 1"), es uno de los miembros de la familia de factores de transcripción de receptores nucleares, activado por una hormona sexual, el estrógeno, y codificado en humanos por el gen HGNC ESR1 .[1] [2] [3]

Estructura[editar]

El receptor de estrógeno es un factor de transcripción activado por ligando compuesto de varios dominios implicados en la unión de la hormona, en la unión al ADN y en la activación de la transcripción.[4] Se han descrito hasta 5 variantes transcripcionales del gen ESR1 obtenidas mediante splicing alternativo, que dan lugar a 5 ARNms diferentes los cuales se diferencian en las regiones 5' no traducidas. Los receptores resultantes de estas variantes muestran menos variabilidad.[5] [1]

Coactivadores[editar]

Los principales coactivadores del receptor de estrógeno alfa son los siguientes:

Interacciones[editar]

El receptor de estrógeno alfa ha demostrado ser capaz de interaccionar con:

Referencias[editar]

  1. a b «Entrez Gene: ESR1 estrogen receptor 1».
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  3. Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J (March 1986). «Sequence and expression of human estrogen receptor complementary DNA». Science (journal) 231 (4742):  pp. 1150–4. doi:10.1126/science.3753802. PMID 3753802. 
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