Receptor de TGF-beta 1

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Receptor del factor de crecimiento transformante beta 1
Protein TGFBR1 PDB 1b6c.png
Estructura tridimensional del receptor de TGF-beta 1.
HUGO 11772
Símbolo TGFBR1
Símbolos alt. ACVRLK4, AAT5, ALK-5, ALK5, SKR4, TGFR-1
Datos genéticos
Locus Cr. 9 q22.33
Bases de datos
Entrez 7046
OMIM 190181
PDB 1b6c
RefSeq NP_004603
UniProt P36897

El receptor del factor de crecimiento transformante beta 1 (TGFBR1) es un receptor de TGF-beta codificado en humanos por el gen HGNC TGFBR1 , corresponde a la actividad enzimática EC 2.7.11.30

Este receptor de TGF-beta 1 forma un complejo heterodimérico con el receptor de TGF-beta 2 cuando se encuentra unido al TGF-beta, transduciendo la señal desde la superficie celular al citoplasma. Este receptor posee actividad serina/treonina quinasa. Se han asociado mutaciones de este gen con el síndrome de aneurisma aórtico Loeys-Dietz (LDAS).[1]

Interacciones[editar]

El receptor de TGF-beta 1 ha demostrado ser capaz de interaccionar con:

Véase también[editar]

Referencias[editar]

  1. «Entrez Gene: TGFBR1 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)».
  2. Mochizuki, Toshiaki; Miyazaki Hideyo, Hara Takane, Furuya Toshio, Imamura Takeshi, Watabe Tetsuro, Miyazono Kohei (Jul. 2004). «Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling». J. Biol. Chem. (United States) 279 (30):  pp. 31568–74. doi:10.1074/jbc.M313977200. ISSN 0021-9258. PMID 15148321. 
  3. Asano, Yoshihide; Ihn Hironobu, Yamane Kenichi, Kubo Masahide, Tamaki Kunihiko (Jan. 2004). «Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts». J. Clin. Invest. (United States) 113 (2):  pp. 253–64. doi:10.1172/JCI16269. ISSN 0021-9738. PMID 14722617. 
  4. Koinuma, Daizo; Shinozaki Masahiko, Komuro Akiyoshi, Goto Kouichiro, Saitoh Masao, Hanyu Aki, Ebina Masahito, Nukiwa Toshihiro, Miyazawa Keiji, Imamura Takeshi, Miyazono Kohei (Dec. 2003). «Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7». EMBO J. (England) 22 (24):  pp. 6458–70. doi:10.1093/emboj/cdg632. ISSN 0261-4189. PMID 14657019. 
  5. Kavsak, P; Rasmussen R K, Causing C G, Bonni S, Zhu H, Thomsen G H, Wrana J L (Dec. 2000). «Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation». Mol. Cell (United States) 6 (6):  pp. 1365–75. ISSN 1097-2765. PMID 11163210. 
  6. Hayashi, H; Abdollah S, Qiu Y, Cai J, Xu Y Y, Grinnell B W, Richardson M A, Topper J N, Gimbrone M A, Wrana J L, Falb D (Jun. 1997). «The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling». Cell (UNITED STATES) 89 (7):  pp. 1165–73. ISSN 0092-8674. PMID 9215638. 
  7. a b Datta, P K; Moses H L (May. 2000). «STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling». Mol. Cell. Biol. (UNITED STATES) 20 (9):  pp. 3157–67. ISSN 0270-7306. PMID 10757800. 
  8. Wang, T; Donahoe P K, Zervos A S (Jul. 1994). «Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12». Science (UNITED STATES) 265 (5172):  pp. 674–6. ISSN 0036-8075. PMID 7518616. 
  9. Liu, F; Ventura F, Doody J, Massagué J (Jul. 1995). «Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs». Mol. Cell. Biol. (UNITED STATES) 15 (7):  pp. 3479–86. ISSN 0270-7306. PMID 7791754. 
  10. Ebner, R; Chen R H, Lawler S, Zioncheck T, Derynck R (Nov. 1993). «Determination of type I receptor specificity by the type II receptors for TGF-beta or activin». Science (UNITED STATES) 262 (5135):  pp. 900–2. ISSN 0036-8075. PMID 8235612. 
  11. Oh, S P; Seki T, Goss K A, Imamura T, Yi Y, Donahoe P K, Li L, Miyazono K, ten Dijke P, Kim S, Li E (Mar. 2000). «Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (6):  pp. 2626–31. ISSN 0027-8424. PMID 10716993. 
  12. a b Razani, B; Zhang X L, Bitzer M, von Gersdorff G, Böttinger E P, Lisanti M P (Mar. 2001). «Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor». J. Biol. Chem. (United States) 276 (9):  pp. 6727–38. doi:10.1074/jbc.M008340200. ISSN 0021-9258. PMID 11102446. 
  13. Kawabata, M; Imamura T, Miyazono K, Engel M E, Moses H L (Dec. 1995). «Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha». J. Biol. Chem. (UNITED STATES) 270 (50):  pp. 29628–31. ISSN 0021-9258. PMID 8530343. 
  14. Griswold-Prenner, I; Kamibayashi C, Maruoka E M, Mumby M C, Derynck R (Nov. 1998). «Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A». Mol. Cell. Biol. (UNITED STATES) 18 (11):  pp. 6595–604. ISSN 0270-7306. PMID 9774674. 
  15. Kawabata, M; Chytil A, Moses H L (Mar. 1995). «Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor». J. Biol. Chem. (UNITED STATES) 270 (10):  pp. 5625–30. ISSN 0021-9258. PMID 7890683. 
  16. Guerrero-Esteo, Mercedes; Sanchez-Elsner Tilman, Letamendia Ainhoa, Bernabeu Carmelo (Aug. 2002). «Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II». J. Biol. Chem. (United States) 277 (32):  pp. 29197–209. doi:10.1074/jbc.M111991200. ISSN 0021-9258. PMID 12015308. 
  17. Barbara, N P; Wrana J L, Letarte M (Jan. 1999). «Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily». J. Biol. Chem. (UNITED STATES) 274 (2):  pp. 584–94. ISSN 0021-9258. PMID 9872992. 
  18. Wrighton, Katharine H; Lin Xia, Feng Xin-Hua (Jul. 2008). «Critical regulation of TGFbeta signaling by Hsp90». Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (27):  pp. 9244–9. doi:10.1073/pnas.0800163105. PMID 18591668. 
  19. Datta, P K; Chytil A, Gorska A E, Moses H L (Dec. 1998). «Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling». J. Biol. Chem. (UNITED STATES) 273 (52):  pp. 34671–4. ISSN 0021-9258. PMID 9856985. 

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