MAP3K7IP2

Proteína de interacción 2 con la MAP quinasa quinasa quinasa 7
	; Estructura tridimensional de la proteína MAP3K7IP2.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 2dae
Identificadores
Símbolos	MAP3K7IP2 (HGNC: 17075) FLJ21885; KIAA0733; TAB2
Identificadores; externos	OMIM: 605101 ; EBI: MAP3K7IP2; GeneCards: Gen MAP3K7IP2; UniProt: MAP3K7IP2;
Locus	Cr. 6 q25.1
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
23118
Q9NYJ8	n/a
NP_055908	n/a
	v; t; e;
	[editar datos en Wikidata]

La proteína de interacción 2 con la MAP quinasa quinasa quinasa 7 (MAP3K7IP2) es una enzima codificada en humanos por el gen MAP3K7IP2.^[1]^[2]^[3]

La proteína MAP3K7IP2 es un activador de MAP3K7/TAK1, que requerida por la activación inducida de IL-1 por parte de NF-κB y MAPK8/JNK. Esta proteína forma un complejo quinasa con TRAF6, MAP3K7 y TAB1, por lo que sirve como un adaptador de unión entre MAP3K7 y TRAF6. MAP3K7IP2, TAB1 y MAP3K7 también participan en la transducción de señales inducida por TNFSF11/RANKL a través de la activación del receptor activador de NF-κB (TNFRSF11A/RANK), que podría regular el desarrollo y función de los osteoclastos.^[3] Se ha asociado con cardiopatías congénitas en seres humanos.^[4]

Interacciones[editar]

La proteína MAP3K7IP2 ha demostrado ser capaz de interaccionar con:

Referencias[editar]

↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr de 1999). «Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro». DNA Res 5 (5): 277-86. PMID 9872452.
↑ ^a ^b ^c ^d ^e Takaesu, G; Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (Apr. de 2000). «TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway». Mol. Cell (UNITED STATES) 5 (4): 649-58. ISSN 1097-2765. PMID 10882101.
↑ ^a ^b «Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2».
↑ Thienpont, Bernard; Zhang, Litu; Postma, Alex V.; Breckpot, Jeroen; Tranchevent, Léon-Charles; Van Loo, Peter; Møllgård, Kjeld; Tommerup, Niels; Bache, Iben; Tümer, Zeynep; van Engelen, Klaartje; Menten, Björn; Mortier, Geert; Waggoner, Darrel; Gewillig, Marc; Moreau, Yves; Devriendt, Koen; Devriendt, Lars Allan (2010). «Haploinsufficiency of TAB2 causes congenital heart defects in humans.». Am J Hum Genet (en inglés) 86 (6): 839-49. PMC 3032066. PMID 20493459. doi:10.1016/j.ajhg.2010.04.011. Consultado el 22 de julio de 2011.
↑ ^a ^b ^c Baek, Sung Hee; Ohgi Kenneth A, Rose David W, Koo Edward H, Glass Christopher K, Rosenfeld Michael G (Jul. de 2002). «Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein». Cell (United States) 110 (1): 55-67. ISSN 0092-8674. PMID 12150997.
↑ Li, Shitao; Wang Lingyan, Dorf Martin E (Jan. de 2009). «PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination». Mol. Cell (United States) 33 (1): 30-42. PMID 19150425. doi:10.1016/j.molcel.2008.11.023.
↑ ^a ^b Ma, Qi; Zhou Li, Shi Huili, Huo Keke (Jun. de 2008). «NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation». Cell. Signal. (England) 20 (6): 1044-51. ISSN 0898-6568. PMID 18299187. doi:10.1016/j.cellsig.2008.01.015.
↑ ^a ^b Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. de 2003). «Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling». EMBO J. (England) 22 (23): 6277-88. ISSN 0261-4189. PMID 14633987. doi:10.1093/emboj/cdg605.
↑ ^a ^b Takaesu, G; Ninomiya-Tsuji J, Kishida S, Li X, Stark G R, Matsumoto K (Apr. de 2001). «Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway». Mol. Cell. Biol. (United States) 21 (7): 2475-84. ISSN 0270-7306. PMID 11259596. doi:10.1128/MCB.21.7.2475-2484.2001.
↑ Walsh, Matthew C; Kim Gregory K, Maurizio Paul L, Molnar Elizabeth E, Choi Yongwon (2008). «TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL». PLoS ONE (United States) 3 (12): e4064. PMID 19112497. doi:10.1371/journal.pone.0004064.
↑ Windheim, Mark; Stafford Margaret, Peggie Mark, Cohen Philip (Mar. de 2008). «Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase». Mol. Cell. Biol. (United States) 28 (5): 1783-91. PMID 18180283. doi:10.1128/MCB.02380-06.
↑ Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. de 2004). «A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway». Nat. Cell Biol. (England) 6 (2): 97-105. ISSN 1465-7392. PMID 14755267. doi:10.1038/ncb1086.
↑ ^a ^b Cheung, Peter C F; Nebreda Angel R, Cohen Philip (Feb. de 2004). «TAB3, a new binding partner of the protein kinase TAK1». Biochem. J. (England) 378 (Pt 1): 27-34. PMID 14670075. doi:10.1042/BJ20031794.

Datos: Q18036737

[pmid9872452-1] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr de 1999). «Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro». DNA Res 5 (5): 277-86. PMID 9872452.

[pmid10882101-2] Takaesu, G; Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (Apr. de 2000). «TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway». Mol. Cell (UNITED STATES) 5 (4): 649-58. ISSN 1097-2765. PMID 10882101.

[entrez_23118-3] «Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2».

[4] Thienpont, Bernard; Zhang, Litu; Postma, Alex V.; Breckpot, Jeroen; Tranchevent, Léon-Charles; Van Loo, Peter; Møllgård, Kjeld; Tommerup, Niels; Bache, Iben; Tümer, Zeynep; van Engelen, Klaartje; Menten, Björn; Mortier, Geert; Waggoner, Darrel; Gewillig, Marc; Moreau, Yves; Devriendt, Koen; Devriendt, Lars Allan (2010). «Haploinsufficiency of TAB2 causes congenital heart defects in humans.». Am J Hum Genet (en inglés) 86 (6): 839-49. PMC 3032066. PMID 20493459. doi:10.1016/j.ajhg.2010.04.011. Consultado el 22 de julio de 2011.

[pmid12150997-5] Baek, Sung Hee; Ohgi Kenneth A, Rose David W, Koo Edward H, Glass Christopher K, Rosenfeld Michael G (Jul. de 2002). «Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein». Cell (United States) 110 (1): 55-67. ISSN 0092-8674. PMID 12150997.

[pmid19150425-6] Li, Shitao; Wang Lingyan, Dorf Martin E (Jan. de 2009). «PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination». Mol. Cell (United States) 33 (1): 30-42. PMID 19150425. doi:10.1016/j.molcel.2008.11.023.

[pmid18299187-7] Ma, Qi; Zhou Li, Shi Huili, Huo Keke (Jun. de 2008). «NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation». Cell. Signal. (England) 20 (6): 1044-51. ISSN 0898-6568. PMID 18299187. doi:10.1016/j.cellsig.2008.01.015.

[pmid14633987-8] Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. de 2003). «Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling». EMBO J. (England) 22 (23): 6277-88. ISSN 0261-4189. PMID 14633987. doi:10.1093/emboj/cdg605.

[pmid11259596-9] Takaesu, G; Ninomiya-Tsuji J, Kishida S, Li X, Stark G R, Matsumoto K (Apr. de 2001). «Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway». Mol. Cell. Biol. (United States) 21 (7): 2475-84. ISSN 0270-7306. PMID 11259596. doi:10.1128/MCB.21.7.2475-2484.2001.

[pmid19112497-10] Walsh, Matthew C; Kim Gregory K, Maurizio Paul L, Molnar Elizabeth E, Choi Yongwon (2008). «TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL». PLoS ONE (United States) 3 (12): e4064. PMID 19112497. doi:10.1371/journal.pone.0004064.

[pmid18180283-11] Windheim, Mark; Stafford Margaret, Peggie Mark, Cohen Philip (Mar. de 2008). «Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase». Mol. Cell. Biol. (United States) 28 (5): 1783-91. PMID 18180283. doi:10.1128/MCB.02380-06.

[pmid14743216-12] Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. de 2004). «A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway». Nat. Cell Biol. (England) 6 (2): 97-105. ISSN 1465-7392. PMID 14755267. doi:10.1038/ncb1086.

[pmid14670075-13] Cheung, Peter C F; Nebreda Angel R, Cohen Philip (Feb. de 2004). «TAB3, a new binding partner of the protein kinase TAK1». Biochem. J. (England) 378 (Pt 1): 27-34. PMID 14670075. doi:10.1042/BJ20031794.

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