Histona deacetilasa 3

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Histona deacetilasa 3
Estructuras disponibles
PDB Búsqueda en Ortholog: PDBeRCSB
Identificadores
Símbolos HDAC3 (HUGO: 4854); RPD3; HD3; RPD3-2
Identificadores externos OMIM605166 MGI1343091 HomoloGene48250 ChEMBL1829 GeneCardsGen HDAC3
Número EC 3.5.1.98
Locus Cr. 5 q31.3
Patrones de expresión RNA
PBB GE HDAC3 216326 s at tn.png
Mayor información
Ortología
Especies Humano Ratón
Entrez 8841 15183
Ensembl Véase HS Véase MM
UniProt O15379 Q3UM33
RefSeq (mRNA) NM_003883 NM_010411
RefSeq (proteína) NCBI NP_003874 NP_034541
Ubicación (UCSC) Chr 5:
141 – 141.02 Mb
Chr 18:
37.94 – 37.95 Mb
PubMed (búsqueda) [1] [2]

La histona deacetilasa 3 (HDAC3) es una enzima codificada en humanos por el gen hdac3.[1] [2]

Función[editar]

Las histonas juegan un papel crucial en la regulación de la transcripción, en la progresión del ciclo celular y en procesos de desarrollo. La acetilación/desacetilación de histonas altera la estructura del cromosoma, variando así la accesibilidad de los factores de transcripción al ADN. La HDAC3 pertenece a la familia de histona deacetilasas acuc/alfa. Esta proteína tiene actividad histona deacetilasa y reprime la transcripción cuando se une a los promotores diana. Podría participar en la regulación de la transcripción a través de su unión con el factor de transcripción con dedos de zinc YY1. HDAC3 también puede reprimir la función de p53 y así modular la proliferación celular y la apoptosis. El gen hdac3 es un potencial supresor tumoral.[3]

Interacciones[editar]

La histona deacetilasa 3 ha demostrado ser capaz de interaccionar con:

Véase también[editar]

Referencias[editar]

  1. Emiliani S, Fischle W, Van Lint C, Al-Abed Y, Verdin E (Apr 1998). «Characterization of a human RPD3 ortholog, HDAC3». Proc Natl Acad Sci U S A 95 (6):  pp. 2795–800. PMID 9501169. 
  2. Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR (Mar 1998). «Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells». Biochem Biophys Res Commun 242 (3):  pp. 648–52. doi:10.1006/bbrc.1997.8033. PMID 9464271. 
  3. «Entrez Gene: HDAC3 histone deacetylase 3».
  4. Petrie, Kevin; Guidez Fabien, Howell Louise, Healy Lyn, Waxman Samuel, Greaves Mel, Zelent Arthur (May. 2003). «The histone deacetylase 9 gene encodes multiple protein isoforms». J. Biol. Chem. (United States) 278 (18):  pp. 16059–72. doi:10.1074/jbc.M212935200. ISSN 0021-9258. PMID 12590135. 
  5. Zhou, X; Richon V M, Rifkind R A, Marks P A (Feb. 2000). «Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (3):  pp. 1056–61. ISSN 0027-8424. PMID 10655483. 
  6. a b c Fischle, W; Dequiedt F, Fillion M, Hendzel M J, Voelter W, Verdin E (Sep. 2001). «Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo». J. Biol. Chem. (United States) 276 (38):  pp. 35826–35. doi:10.1074/jbc.M104935200. ISSN 0021-9258. PMID 11466315. 
  7. a b Fajas, Lluis; Egler Viviane, Reiter Raphael, Hansen Jacob, Kristiansen Karsten, Debril Marie-Bernard, Miard Stéphanie, Auwerx Johan (Dec. 2002). «The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation». Dev. Cell (United States) 3 (6):  pp. 903–10. ISSN 1534-5807. PMID 12479814. 
  8. Lai, A; Lee J M, Yang W M, DeCaprio J A, Kaelin W G, Seto E, Branton P E (Oct. 1999). «RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins». Mol. Cell. Biol. (UNITED STATES) 19 (10):  pp. 6632–41. ISSN 0270-7306. PMID 10490602. 
  9. Nicolas, E; Ait-Si-Ali S, Trouche D (Aug. 2001). «The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein». Nucleic Acids Res. (England) 29 (15):  pp. 3131–6. PMID 11470869. 
  10. Li, Guangjin; Franco Peter J, Wei Li-Na (Oct. 2003). «Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2». Biochem. Biophys. Res. Commun. (United States) 310 (2):  pp. 384–90. ISSN 0006-291X. PMID 14521922. 
  11. a b c Franco, Peter J; Li Guangjin, Wei Li-Na (Aug. 2003). «Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase». Mol. Cell. Endocrinol. (Ireland) 206 (1-2):  pp. 1–12. ISSN 0303-7207. PMID 12943985. 
  12. Franco, P J; Farooqui M, Seto E, Wei L N (Aug. 2001). «The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases». Mol. Endocrinol. (United States) 15 (8):  pp. 1318–28. ISSN 0888-8809. PMID 11463856. 
  13. Baek, Sung Hee; Ohgi Kenneth A, Rose David W, Koo Edward H, Glass Christopher K, Rosenfeld Michael G (Jul. 2002). «Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein». Cell (United States) 110 (1):  pp. 55–67. ISSN 0092-8674. PMID 12150997. 
  14. Shi, Yanhong; Hon Michelle, Evans Ronald M (Mar. 2002). «The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5):  pp. 2613–8. doi:10.1073/pnas.052707099. ISSN 0027-8424. PMID 11867749. 
  15. Wen, Yu-Der; Cress W Douglas, Roy Ananda L, Seto Edward (Jan. 2003). «Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I». J. Biol. Chem. (United States) 278 (3):  pp. 1841–7. doi:10.1074/jbc.M206528200. ISSN 0021-9258. PMID 12393887. 
  16. Tussié-Luna, María Isabel; Bayarsaihan Dashzeveg, Seto Edward, Ruddle Frank H, Roy Ananda L (Oct. 2002). «Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (20):  pp. 12807–12. doi:10.1073/pnas.192464499. ISSN 0027-8424. PMID 12239342. 
  17. a b Grozinger, C M; Hassig C A, Schreiber S L (Apr. 1999). «Three proteins define a class of human histone deacetylases related to yeast Hda1p». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9):  pp. 4868–73. ISSN 0027-8424. PMID 10220385. 
  18. a b c d Fischle, Wolfgang; Dequiedt Franck, Hendzel Michael J, Guenther Matthew G, Lazar Mitchell A, Voelter Wolfgang, Verdin Eric (Jan. 2002). «Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR». Mol. Cell (United States) 9 (1):  pp. 45–57. ISSN 1097-2765. PMID 11804585. 
  19. a b c d Zhang, Jinsong; Kalkum Markus, Chait Brian T, Roeder Robert G (Mar. 2002). «The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2». Mol. Cell (United States) 9 (3):  pp. 611–23. ISSN 1097-2765. PMID 11931768. 
  20. a b Grozinger, C M; Schreiber S L (Jul. 2000). «Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14):  pp. 7835–40. doi:10.1073/pnas.140199597. ISSN 0027-8424. PMID 10869435. 
  21. Chen Lf; Fischle W, Verdin E, Greene W C (Aug. 2001). «Duration of nuclear NF-kappaB action regulated by reversible acetylation». Science (United States) 293 (5535):  pp. 1653–7. doi:10.1126/science.1062374. ISSN 0036-8075. PMID 11533489. 
  22. Mahlknecht, Ulrich; Will Jutta, Varin Audrey, Hoelzer Dieter, Herbein Georges (Sep. 2004). «Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression». J. Immunol. (United States) 173 (6):  pp. 3979–90. ISSN 0022-1767. PMID 15356147. 
  23. a b Guenther, M G; Lane W S, Fischle W, Verdin E, Lazar M A, Shiekhattar R (May. 2000). «A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness». Genes Dev. (UNITED STATES) 14 (9):  pp. 1048–57. ISSN 0890-9369. PMID 10809664. 
  24. a b c Yoon, Ho-Geun; Chan Doug W, Reynolds Albert B, Qin Jun, Wong Jiemin (Sep. 2003). «N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso». Mol. Cell (United States) 12 (3):  pp. 723–34. ISSN 1097-2765. PMID 14527417. 
  25. a b Yoon, Ho-Geun; Chan Doug W, Huang Zhi-Qing, Li Jiwen, Fondell Joseph D, Qin Jun, Wong Jiemin (Mar. 2003). «Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1». EMBO J. (England) 22 (6):  pp. 1336–46. doi:10.1093/emboj/cdg120. ISSN 0261-4189. PMID 12628926. 
  26. a b Li, J; Wang J, Wang J, Nawaz Z, Liu J M, Qin J, Wong J (Aug. 2000). «Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3». EMBO J. (ENGLAND) 19 (16):  pp. 4342–50. doi:10.1093/emboj/19.16.4342. ISSN 0261-4189. PMID 10944117. 
  27. a b Underhill, C; Qutob M S, Yee S P, Torchia J (Dec. 2000). «A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1». J. Biol. Chem. (UNITED STATES) 275 (51):  pp. 40463–70. doi:10.1074/jbc.M007864200. ISSN 0021-9258. PMID 11013263. 
  28. Petre-Draviam, Christin E; Williams Erin B, Burd Craig J, Gladden Andrew, Moghadam Hamed, Meller Jaroslaw, Diehl J Alan, Knudsen Karen E (Jan. 2005). «A central domain of cyclin D1 mediates nuclear receptor corepressor activity». Oncogene (England) 24 (3):  pp. 431–44. doi:10.1038/sj.onc.1208200. ISSN 0950-9232. PMID 15558026. 
  29. Lin, Huei-Min; Zhao Li, Cheng Sheue-Yann (Aug. 2002). «Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors». J. Biol. Chem. (United States) 277 (32):  pp. 28733–41. doi:10.1074/jbc.M203380200. ISSN 0021-9258. PMID 12048199. 
  30. a b Guenther, Matthew G; Yu Jiujiu, Kao Gary D, Yen Tim J, Lazar Mitchell A (Dec. 2002). «Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex». Genes Dev. (United States) 16 (24):  pp. 3130–5. doi:10.1101/gad.1037502. ISSN 0890-9369. PMID 12502735. 
  31. Vaute, Olivier; Nicolas Estelle, Vandel Laurence, Trouche Didier (Jan. 2002). «Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases». Nucleic Acids Res. (England) 30 (2):  pp. 475–81. PMID 11788710. 
  32. Hoogeveen, André T; Rossetti Stefano, Stoyanova Violeta, Schonkeren Joris, Fenaroli Angelia, Schiaffonati Luisa, van Unen Leontine, Sacchi Nicoletta (Sep. 2002). «The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies». Oncogene (England) 21 (43):  pp. 6703–12. doi:10.1038/sj.onc.1205882. ISSN 0950-9232. PMID 12242670. 
  33. Amann, J M; Nip J, Strom D K, Lutterbach B, Harada H, Lenny N, Downing J R, Meyers S, Hiebert S W (Oct. 2001). «ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain». Mol. Cell. Biol. (United States) 21 (19):  pp. 6470–83. ISSN 0270-7306. PMID 11533236. 
  34. Yang, W M; Yao Y L, Sun J M, Davie J R, Seto E (Oct. 1997). «Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family». J. Biol. Chem. (UNITED STATES) 272 (44):  pp. 28001–7. ISSN 0021-9258. PMID 9346952. 
  35. Yao, Y L; Yang W M, Seto E (Sep. 2001). «Regulation of transcription factor YY1 by acetylation and deacetylation». Mol. Cell. Biol. (United States) 21 (17):  pp. 5979–91. ISSN 0270-7306. PMID 11486036. 
  36. Schroeder, Tania M; Kahler Rachel A, Li Xiaodong, Westendorf Jennifer J (Oct. 2004). «Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation». J. Biol. Chem. (United States) 279 (40):  pp. 41998–2007. doi:10.1074/jbc.M403702200. ISSN 0021-9258. PMID 15292260. 
  37. Watamoto, Kouichi; Towatari Masayuki, Ozawa Yukiyasu, Miyata Yasuhiko, Okamoto Mitsunori, Abe Akihiro, Naoe Tomoki, Saito Hidehiko (Dec. 2003). «Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation». Oncogene (England) 22 (57):  pp. 9176–84. doi:10.1038/sj.onc.1206902. ISSN 0950-9232. PMID 14668799. 
  38. Ozawa, Y; Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H (Oct. 2001). «Histone deacetylase 3 associates with and represses the transcription factor GATA-2». Blood (United States) 98 (7):  pp. 2116–23. ISSN 0006-4971. PMID 11567998. 
  39. Wu, W S; Vallian S, Seto E, Yang W M, Edmondson D, Roth S, Chang K S (Apr. 2001). «The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases». Mol. Cell. Biol. (United States) 21 (7):  pp. 2259–68. doi:10.1128/MCB.21.7.2259-2268.2001. ISSN 0270-7306. PMID 11259576. 
  40. Tan, Fengwei; Lu Lifang, Cai Yun, Wang Jinglan, Xie Yunfei, Wang Lin, Gong Yanhua, Xu Bing-E, Wu Jun, Luo Ying, Qiang Boqin, Yuan Jiangang, Sun Xiaoqing, Peng Xiaozhong (Jul. 2008). «Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells». Proteomics (Germany) 8 (14):  pp. 2885–96. doi:10.1002/pmic.200700887. PMID 18655026. 

Enlaces externos[editar]