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Proteína 2 de cuatro dominios y medio LIM

Estructura tridimensional de la proteína FHL2.
Estructuras disponibles
PDB Búsqueda en Ortholog: PDBeRCSB
Símbolos FHL2 (HUGO: 3703); AAG11, DRAL, SLIM3
Identificadores externos OMIM602633 MGI1338762 HomoloGene20372 GeneCardsGen FHL2
Locus Cr. 2 q12.2
Patrones de expresión RNA
PBB GE FHL2 202949 s at tn.png
Mayor información
Especies Humano Ratón
Entrez 2274 14200
Ensembl Véase HS Véase MM
UniProt Q14192 O70433
RefSeq (mRNA) NM_001039492 NM_010212
RefSeq (proteína) NCBI NP_001034581 NP_034342
Ubicación (UCSC) Chr 2:
105.97 – 106.05 Mb
Chr 1:
43.12 – 43.16 Mb
PubMed (búsqueda) [1] [2]

La proteína 2 de cuatro dominios y medio LIM (FHL2) es una proteína codificada en humanos por el gen fhl2.[1]

Las proteínas LIM se caracterizan por la posesión de un motivo con dos dedos de zinc altamente conservado, denominado dominio LIM. En el caso de FHL2, esta proteína posee cuatro de estos dominios LIM más un dominio que podría ser la mitad de un dominio LIM.[2]


La proteína FHL2 ha demostrado ser capaz de interaccionar con:


  1. Morgan MJ, Madgwick AJ (Oct 1996). «Slim defines a novel family of LIM-proteins expressed in skeletal muscle». Biochem Biophys Res Commun 225 (2):  pp. 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811. 
  2. «Entrez Gene: FHL2 four and a half LIM domains 2».
  3. Wei, Yu; Renard Claire-Angélique, Labalette Charlotte, Wu Yuanfei, Lévy Laurence, Neuveut Christine, Prieur Xavier, Flajolet Marc, Prigent Sylvie, Buendia Marie-Annick (Feb. 2003). «Identification of the LIM protein FHL2 as a coactivator of beta-catenin». J. Biol. Chem. (United States) 278 (7):  pp. 5188–94. doi:10.1074/jbc.M207216200. ISSN 0021-9258. PMID 12466281. 
  4. Lange, Stephan; Auerbach Daniel, McLoughlin Patricia, Perriard Evelyne, Schäfer Beat W, Perriard Jean-Claude, Ehler Elisabeth (Dec. 2002). «Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2». J. Cell. Sci. (England) 115 (Pt 24):  pp. 4925–36. ISSN 0021-9533. PMID 12432079. 
  5. McLoughlin, Patricia; Ehler Elisabeth, Carlile Graeme, Licht Jonathan D, Schäfer Beat W (Oct. 2002). «The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein». J. Biol. Chem. (United States) 277 (40):  pp. 37045–53. doi:10.1074/jbc.M203336200. ISSN 0021-9258. PMID 12145280. 
  6. a b c d e Wixler, V; Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (Oct. 2000). «The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes». J. Biol. Chem. (UNITED STATES) 275 (43):  pp. 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324. 
  7. Müller, J M; Isele U, Metzger E, Rempel A, Moser M, Pscherer A, Breyer T, Holubarsch C, Buettner R, Schüle R (Feb. 2000). «FHL2, a novel tissue-specific coactivator of the androgen receptor». EMBO J. (ENGLAND) 19 (3):  pp. 359–69. doi:10.1093/emboj/19.3.359. ISSN 0261-4189. PMID 10654935. 
  8. Samson, Thomas; Smyth Neil, Janetzky Stefanie, Wendler Olaf, Müller Judith M, Schüle Roland, von der Mark Helga, von der Mark Klaus, Wixler Viktor (Jul. 2004). «The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor». J. Biol. Chem. (United States) 279 (27):  pp. 28641–52. doi:10.1074/jbc.M312894200. ISSN 0021-9258. PMID 15117962. 
  9. a b Fimia, G M; De Cesare D, Sassone-Corsi P (Nov. 2000). «A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM». Mol. Cell. Biol. (UNITED STATES) 20 (22):  pp. 8613–22. ISSN 0270-7306. PMID 11046156. 
  10. Purcell, Nicole H; Darwis Dina, Bueno Orlando F, Müller Judith M, Schüle Roland, Molkentin Jeffery D (Feb. 2004). «Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes». Mol. Cell. Biol. (United States) 24 (3):  pp. 1081–95. ISSN 0270-7306. PMID 14729955. 
  11. Ng, Enders Kai On; Chan Kwok Keung, Wong Chi Hang, Tsui Stephen Kwok Wing, Ngai Sai Ming, Lee Simon Ming Yuen, Kotaka Masayo, Lee Cheuk Yu, Waye Mary Miu Yee, Fung Kwok Pui (2002). «Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220». J. Cell. Biochem. (United States) 84 (3):  pp. 556–66. ISSN 0730-2312. PMID 11813260. 
  12. Yan, Jinghua; Zhu Jianhua, Zhong Hongjun, Lu Qiujun, Huang Cuifen, Ye Qinong (Oct. 2003). «BRCA1 interacts with FHL2 and enhances FHL2 transactivation function». FEBS Lett. (Netherlands) 553 (1-2):  pp. 183–9. ISSN 0014-5793. PMID 14550570. 
  13. Yan, Jing-Hua; Ye Qi-Nong, Zhu Jian-Hua, Zhong Hong-Jun, Zheng Hui-Yong, Huang Cui-Fen (Dec. 2003). «[Isolation and characterization of a BRCA1-interacting protein]». Yi Chuan Xue Bao (China) 30 (12):  pp. 1161–6. ISSN 0379-4172. PMID 14986435. 
  14. Li, H Y; Ng E K, Lee S M, Kotaka M, Tsui S K, Lee C Y, Fung K P, Waye M M (2001). «Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)». J. Cell. Biochem. (United States) 80 (3):  pp. 293–303. ISSN 0730-2312. PMID 11135358. 
  15. Amaar, Yousef G; Thompson Garrett R, Linkhart Thomas A, Chen Shin-Tai, Baylink David J, Mohan Subburaman (Apr. 2002). «Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2)». J. Biol. Chem. (United States) 277 (14):  pp. 12053–60. doi:10.1074/jbc.M110872200. ISSN 0021-9258. PMID 11821401. 
  16. Bai, Shuting; Zha Jikun, Zhao Haibo, Ross F Patrick, Teitelbaum Steven L (Nov. 2008). «Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts». J. Biol. Chem. (United States) 283 (45):  pp. 30861–7. doi:10.1074/jbc.M802525200. ISSN 0021-9258. PMID 18768464. 
  17. Tanahashi, H; Tabira T (Sep. 2000). «Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein». Hum. Mol. Genet. (ENGLAND) 9 (15):  pp. 2281–9. ISSN 0964-6906. PMID 11001931. 

Enlaces externos[editar]