CTBP2

Proteína de unión C-terminal 2
	; Estructura tridimensional de la proteína CTBP2.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 2ome
Identificadores
Símbolo	CTBP2 (HGNC: 2495)
Identificadores; externos	OMIM: 602619 ; HomoloGene: 75187 ; EBI: CTBP2; GeneCards: Gen CTBP2; UniProt: CTBP2;
Locus	Cr. 10 [1]
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
1488	13017
Véase HS	Véase MM
P56545	P56546
NM_001083914	NM_001170744
NP_001077383	NP_001164215
Cr. 10:; 126.68 – 126.85 Mb	Cr. 7:; 132.99 – 133.12 Mb
[2] ;	[3]
	v; t; e;
	[editar datos en Wikidata]

La proteína de unión C-terminal 2 (CTBP2) es una proteína codificada en humanos por el gen ctbp2.^[1]^[2]^[3]

El gen ctbp2 produce transcritos alternativos que codifica dos isoformas diferentes de la proteína. Una de ellas es un represor transcripcional, mientras que la otra isoforma es un componente principal de un proceso especializado de sinapsis conocido como cintas sinápticas. Ambas isoformas contienen un dominio de unión a NAD⁺ similar a los que poseen las deshidrogenasas de 2-hidroxiácido dependientes de NAD⁺. Una porción de la región 3' no codificante fue utilizada para mapear este gen, que fue localizado en el locus 21q21.3. Sin embargo, se pudieron encontrar loci similares en otras partes del genoma. Un análisis con el programa Blast demostró que este gen está presente en el cromosoma 10.^[3]

Interacciones[editar]

La proteína CTBP2 ha demostrado ser capaz de interaccionar con:

Referencias[editar]

↑ Katsanis N, Fisher EM (Apr de 1998). «A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3». Genomics 47 (2): 294-9. PMID 9479502. doi:10.1006/geno.1997.5115.
↑ Chinnadurai G (Feb de 2002). «CtBP, an unconventional transcriptional corepressor in development and oncogenesis». Mol Cell 9 (2): 213-24. PMID 11864595.
↑ ^a ^b «Entrez Gene: CTBP2 C-terminal binding protein 2».
↑ ^a ^b Turner, Jeremy; Nicholas Hannah, Bishop David, Matthews Jacqueline M, Crossley Merlin (Apr. de 2003). «The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2». J. Biol. Chem. (United States) 278 (15): 12786-95. ISSN 0021-9258. PMID 12556451. doi:10.1074/jbc.M300587200.
↑ Murakami, A; Ishida S, Thurlow J, Revest J M, Dickson C (Aug. de 2001). «SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter». Nucleic Acids Res. (England) 29 (16): 3347-55. PMID 11504872.
↑ Turner, J; Crossley M (Sep. de 1998). «Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators». EMBO J. (ENGLAND) 17 (17): 5129-40. ISSN 0261-4189. PMID 9724649. doi:10.1093/emboj/17.17.5129.
↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.
↑ Castet, Audrey; Boulahtouf Abdelhay, Versini Gwennaëlle, Bonnet Sandrine, Augereau Patrick, Vignon Françoise, Khochbin Saadi, Jalaguier Stéphan, Cavaillès Vincent (2004). «Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition». Nucleic Acids Res. (England) 32 (6): 1957-66. PMID 15060175. doi:10.1093/nar/gkh524.
↑ Holmes, M; Turner J; Fox A; Chisholm O; Crossley M; Chong B (Aug. de 1999). «hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation». J. Biol. Chem. (UNITED STATES) 274 (33): 23491-8. ISSN 0021-9258. PMID 10438528.
↑ Mirnezami, Alexander H; Campbell Sandra J, Darley Matthew, Primrose John N, Johnson Peter W M, Blaydes Jeremy P (Jul. de 2003). «Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription». Curr. Biol. (England) 13 (14): 1234-9. ISSN 0960-9822. PMID 12867035.
↑ van Vliet, J; Turner J; Crossley M (mayo. de 2000). «Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription». Nucleic Acids Res. (ENGLAND) 28 (9): 1955-62. PMID 10756197.

Datos: Q17911327

[pmid9479502-1] Katsanis N, Fisher EM (Apr de 1998). «A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3». Genomics 47 (2): 294-9. PMID 9479502. doi:10.1006/geno.1997.5115.

[pmid11864595-2] Chinnadurai G (Feb de 2002). «CtBP, an unconventional transcriptional corepressor in development and oncogenesis». Mol Cell 9 (2): 213-24. PMID 11864595.

[entrez-3] «Entrez Gene: CTBP2 C-terminal binding protein 2».

[pmid12556451-4] Turner, Jeremy; Nicholas Hannah, Bishop David, Matthews Jacqueline M, Crossley Merlin (Apr. de 2003). «The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2». J. Biol. Chem. (United States) 278 (15): 12786-95. ISSN 0021-9258. PMID 12556451. doi:10.1074/jbc.M300587200.

[pmid11504872-5] Murakami, A; Ishida S, Thurlow J, Revest J M, Dickson C (Aug. de 2001). «SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter». Nucleic Acids Res. (England) 29 (16): 3347-55. PMID 11504872.

[pmid9724649-6] Turner, J; Crossley M (Sep. de 1998). «Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators». EMBO J. (ENGLAND) 17 (17): 5129-40. ISSN 0261-4189. PMID 9724649. doi:10.1093/emboj/17.17.5129.

[pmid16189514-7] Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.

[pmid15060175-8] Castet, Audrey; Boulahtouf Abdelhay, Versini Gwennaëlle, Bonnet Sandrine, Augereau Patrick, Vignon Françoise, Khochbin Saadi, Jalaguier Stéphan, Cavaillès Vincent (2004). «Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition». Nucleic Acids Res. (England) 32 (6): 1957-66. PMID 15060175. doi:10.1093/nar/gkh524.

[pmid10438528-9] Holmes, M; Turner J; Fox A; Chisholm O; Crossley M; Chong B (Aug. de 1999). «hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation». J. Biol. Chem. (UNITED STATES) 274 (33): 23491-8. ISSN 0021-9258. PMID 10438528.

[pmid12867035-10] Mirnezami, Alexander H; Campbell Sandra J, Darley Matthew, Primrose John N, Johnson Peter W M, Blaydes Jeremy P (Jul. de 2003). «Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription». Curr. Biol. (England) 13 (14): 1234-9. ISSN 0960-9822. PMID 12867035.

[pmid10756197-11] van Vliet, J; Turner J; Crossley M (mayo. de 2000). «Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription». Nucleic Acids Res. (ENGLAND) 28 (9): 1955-62. PMID 10756197.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]