CSF-1

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Macrophage colony-stimulating factor (MCSF) o también Colony stimulating factor 1 (CSF-1), es una citoquina secretada que induce a las células madre hemopoyéticas a diferenciarse a macrófago u otros tipos celulares relacionados. Las células eucarióticas también producen M-CSF para combatir infecciones virales intracelulares. M-CSF se une a su receptor, el Colony stimulating factor 1 receptor. Puede que el M-CSF también esté involucrado en el desarrollo de la placenta.

Estructura[editar]

Es una citoquina. La forma activa de la proteína se encuentra extracelularmente en forma de homodímero, estando unidos los monómeros por un enlace disulfuro. Se piensa que esta forma es producida a partir del procesamiento proteolítico de precursores unidos a membrana.

Se han encontrado cuatro variantes transcripcionales codificando tres isoformas diferentes.[1]

Se ha demostrado que MCSF interacciona con PIK3R2.[2]

Referencias[editar]

  1. "Entrez Gene: CSF1 colony stimulating factor 1 (macrophage)". [1]
  2. Gout, I; Dhand R, Panayotou G, Fry M J, Hiles I, Otsu M, Waterfield M D (Dec. 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". Biochem. J. (ENGLAND) 288 ( Pt 2): 395-405. ISSN 0264-6021. PMID 1334406.

Lecturas adicionales[editar]

  • Stanley ER, Berg KL, Einstein DB, et al. (1995). "The biology and action of colony stimulating factor-1.". Stem Cells 12 Suppl 1: 15–24; discussion 25. PMID 7696959.
  • Alterman RL, Stanley ER (1994). "Colony stimulating factor-1 expression in human glioma.". Mol. Chem. Neuropathol. 21 (2-3): 177–88. doi:10.1007/BF02815350. PMID 8086034.
  • Stanley ER, Berg KL, Einstein DB, et al. (1997). "Biology and action of colony--stimulating factor-1.". Mol. Reprod. Dev. 46 (1): 4–10. doi:10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V. PMID 8981357.
  • Sweet MJ, Hume DA (2004). "CSF-1 as a regulator of macrophage activation and immune responses.". Arch. Immunol. Ther. Exp. (Warsz.) 51 (3): 169–77. PMID 12894871.
  • Mroczko B, Szmitkowski M (2005). "Hematopoietic cytokines as tumor markers.". Clin. Chem. Lab. Med. 42 (12): 1347–54. doi:10.1515/CCLM.2004.253. PMID 15576295.
  • Pandit J, Bohm A, Jancarik J, et al. (1993). "Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor.". Science 258 (5086): 1358–62. doi:10.1126/science.1455231. PMID 1455231.
  • Suzu S, Ohtsuki T, Yanai N, et al. (1992). "Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species.". J. Biol. Chem. 267 (7): 4345–8. PMID 1531650.
  • Saltman DL, Dolganov GM, Hinton LM, Lovett M (1992). "Reassignment of the human macrophage colony stimulating factor gene to chromosome 1p13-21.". Biochem. Biophys. Res. Commun. 182 (3): 1139–43. doi:10.1016/0006-291X(92)91850-P. PMID 1540160.
  • Praloran V, Chevalier S, Gascan H (1992). "Macrophage colony-stimulating factor is produced by activated T lymphocytes in vitro and is detected in vivo in T cells from reactive lymph nodes.". Blood 79 (9): 2500–1. PMID 1571567.
  • Price LK, Choi HU, Rosenberg L, Stanley ER (1992). "The predominant form of secreted colony stimulating factor-1 is a proteoglycan.". J. Biol. Chem. 267 (4): 2190–9. PMID 1733926.
  • Pampfer S, Tabibzadeh S, Chuan FC, Pollard JW (1992). "Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1.". Mol. Endocrinol. 5 (12): 1931–8. doi:10.1210/mend-5-12-1931. PMID 1791839.
  • Stein J, Borzillo GV, Rettenmier CW (1990). "Direct stimulation of cells expressing receptors for macrophage colony-stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1.". Blood 76 (7): 1308–14. PMID 2145044.
  • Sherr CJ, Rettenmier CW, Sacca R, et al. (1985). "The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1.". Cell 41 (3): 665–76. doi:10.1016/S0092-8674(85)80047-7. PMID 2408759.
  • Cerretti DP, Wignall J, Anderson D, et al. (1988). "Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene.". Mol. Immunol. 25 (8): 761–70. doi:10.1016/0161-5890(88)90112-5. PMID 2460758.
  • Takahashi M, Hirato T, Takano M, et al. (1989). "Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its in vitro biological activity: molecular cloning and expression of carboxyl-terminal deletion mutants of human M-CSF.". Biochem. Biophys. Res. Commun. 161 (2): 892–901. doi:10.1016/0006-291X(89)92683-1. PMID 2660794.
  • Kawasaki ES, Ladner MB, Wang AM, et al. (1985). "Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1).". Science 230 (4723): 291–6. doi:10.1126/science.2996129. PMID 2996129.
  • Rettenmier CW, Roussel MF, Ashmun RA, et al. (1987). "Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes.". Mol. Cell. Biol. 7 (7): 2378–87. PMID 3039346.
  • Takahashi M, Hong YM, Yasuda S, et al. (1988). "Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis.". Biochem. Biophys. Res. Commun. 152 (3): 1401–9. doi:10.1016/S0006-291X(88)80441-8. PMID 3259875.
  • Rettenmier CW, Roussel MF (1989). "Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs.". Mol. Cell. Biol. 8 (11): 5026–34. PMID 3264877.
  • Wong GG, Temple PA, Leary AC, et al. (1987). "Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.". Science 235 (4795): 1504–8. doi:10.1126/science.3493529. PMID 3493529.